node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
STH2502 | STH3190 | STH2502 | STH3190 | Putative 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Formiminotetrahydrofolate cyclodeaminase. | 0.542 |
STH2502 | fhs | STH2502 | STH3189 | Putative 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.988 |
STH2502 | fmt | STH2502 | STH1344 | Putative 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.927 |
STH2502 | folD | STH2502 | STH1847 | Putative 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.984 |
STH2502 | gcvT | STH2502 | STH1922 | Putative 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.934 |
STH2502 | glyA | STH2502 | STH1917 | Putative 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.948 |
STH2502 | purH | STH2502 | STH2850 | Putative 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase. | 0.929 |
STH2502 | purN | STH2502 | STH2852 | Putative 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.930 |
STH3190 | STH2502 | STH3190 | STH2502 | Formiminotetrahydrofolate cyclodeaminase. | Putative 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.542 |
STH3190 | fhs | STH3190 | STH3189 | Formiminotetrahydrofolate cyclodeaminase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.989 |
STH3190 | fmt | STH3190 | STH1344 | Formiminotetrahydrofolate cyclodeaminase. | 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.920 |
STH3190 | folD | STH3190 | STH1847 | Formiminotetrahydrofolate cyclodeaminase. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.971 |
STH3190 | gcvT | STH3190 | STH1922 | Formiminotetrahydrofolate cyclodeaminase. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.933 |
STH3190 | purH | STH3190 | STH2850 | Formiminotetrahydrofolate cyclodeaminase. | Phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase. | 0.907 |
STH3190 | purN | STH3190 | STH2852 | Formiminotetrahydrofolate cyclodeaminase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.913 |
fhs | STH2502 | STH3189 | STH2502 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Putative 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.988 |
fhs | STH3190 | STH3189 | STH3190 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Formiminotetrahydrofolate cyclodeaminase. | 0.989 |
fhs | fmt | STH3189 | STH1344 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.546 |
fhs | folD | STH3189 | STH1847 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.998 |
fhs | gcvT | STH3189 | STH1922 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.951 |