STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ46157.1ATP-dependent DNA helicase, RecQ family; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR014001:IPR001650:IPR014021:IPR011545:IPR 018329; KEGG: cyc:PCC7424_1034 ATP-dependent DNA helicase, RecQ family; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: ATP-dependent DNA helicase RecQ; TIGRFAM: ATP-dependent DNA helicase, RecQ family. (475 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
 
 0.967
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.942
AFZ47545.1
PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; COGs: COG0513 Superfamily II DNA and RNA helicase; InterProIPR011545:IPR001650:IPR000629:IPR014021:IPR 014014:IPR014001; KEGG: cyu:UCYN_06480 DNA/RNA helicase, superfamily II; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: ATP-dependent RNA helicase; DeaD; Belongs to the DEAD box helicase family.
 
0.936
AFZ47777.1
ATP-dependent DNA helicase RecQ; PFAM: Helicase conserved C-terminal domain; RQC domain; HRDC domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR011545:IPR001650:IPR018982:IPR002121:IPR 014021:IPR006293:IPR018329:IPR014001; KEGG: cyc:PCC7424_1427 ATP-dependent DNA helicase RecQ; PFAM: RQC domain; DEAD/DEAH box helicase domain protein; helicase domain protein; HRDC domain protein; SMART: helicase domain protein; DEAD-like helicase; HRDC domain protein; SPTR: ATP-dependen [...]
  
  
 
0.920
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 0.872
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 0.809
AFZ46156.1
PFAM: Protein phosphatase 2C; COGs: COG0631 Serine/threonine protein phosphatase; InterPro IPR001932:IPR014045; KEGG: cyt:cce_2930 hypothetical protein; PFAM: Protein phosphatase 2C-like; SMART: protein phosphatase 2C domain protein; SPTR: Putative uncharacterized protein.
  
 
 0.790
AFZ46158.1
Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; COGs: COG2236 phosphoribosyltransferase; KEGG: cyt:cce_4678 phosphoribosyltransferase; SPTR: Phosphoribosyltransferase.
       0.773
AFZ46587.1
PFAM: SNF2 Helicase protein; Helicase conserved C-terminal domain; SNF2 family N-terminal domain; COGs: COG0553 Superfamily II DNA/RNA helicase SNF2 family; InterPro IPR000330:IPR001650:IPR014021:IPR014001; KEGG: cyc:PCC7424_3806 non-specific serine/threonine protein kinase; PFAM: SNF2-related protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: Non-specific serine/threonine protein kinase.
 
 
 
 0.763
sbcD
Exodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 0.705
Your Current Organism:
Cyanobacterium stanieri
NCBI taxonomy Id: 292563
Other names: C. stanieri PCC 7202, Cyanobacterium stanieri PCC 7202, Synechococcus cedrorum CCAP 14792a (no longer available), Synechococcus cedrorum CCAP 14792b (no longer available), Synechococcus cedrorum M137/1a, Synechococcus cedrorum SAG 88.79, Synechococcus sp. ATCC 29140, Synechococcus sp. PCC 7202
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