STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ46459.1PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; COGs: COG0372 Citrate synthase; InterPro IPR002020:IPR019810:IPR011278; KEGG: cyh:Cyan8802_1408 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; SPTR: 2-methylcitrate synthase/citrate synthase II; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family. (380 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.985
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.982
AFZ46967.1
Aconitase; PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; TIGRFAM: aconitate hydratase 2; COGs: COG1049 Aconitase B; InterPro IPR004406:IPR018136:IPR015929:IPR001030; KEGG: syp:SYNPCC7002_A1683 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; PFAM: Aconitase B; aconitate hydratase domain-containing protein; PRIAM: Aconitate hydratase; SPTR: Aconitate hydratase 2; TIGRFAM: aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family.
  
 
 0.979
AFZ48454.1
Catalytic domain-containing protein of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme; TIGRFAM: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078:IPR003016; KEGG: syp:SYNPCC7002_A0110 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: catalytic domain-containing protein of components of various [...]
  
 0.979
AFZ46233.1
PFAM: ATP-grasp domain; COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR011761:IPR013650; KEGG: cyh:Cyan8802_0543 ATP-grasp domain protein; PFAM: ATP-grasp domain protein; SPTR: ATP-grasp domain protein.
 
 
 0.973
AFZ46044.1
PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type; COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR019818:IPR001804:IPR004439; KEGG: cyp:PCC8801_3969 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; SPTR: Isocitrate dehydrogenase [NADP]; TIGRFAM: isocitrate dehydrogenase, NADP-dependent.
 
 
 0.965
fumC
Fumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
 0.911
AFZ48453.1
PFAM: Proline dehydrogenase; Aldehyde dehydrogenase family; TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR002872:IPR015590:IPR016160:IPR005932; KEGG: cyc:PCC7424_1002 delta-1-pyrroline-5-carboxylate dehydrogenase; PFAM: Aldehyde Dehydrogenase; Proline dehydrogenase; SPTR: Delta-1-pyrroline-5-carboxylate dehydrogenase; TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase; L-proline dehydrogenase; Belongs to the aldehyde dehydrogenase family.
  
 
 0.910
AFZ47551.1
PFAM: Aldehyde dehydrogenase family; COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590; KEGG: cyh:Cyan8802_4209 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Aldehyde Dehydrogenase.
 
 0.898
AFZ47161.1
Malic protein NAD-binding protein; PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; ACT domain; COGs: COG0281 Malic enzyme; InterProIPR005829:IPR015884:IPR001891:IPR002912:IPR 012301:IPR012302; KEGG: cyc:PCC7424_1195 malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic protein NAD-binding; malic protein domain protein; amino acid-binding ACT domain protein; SPTR: Malate dehydrogenase (Oxaloacetate-decarboxylating).
  
 0.895
Your Current Organism:
Cyanobacterium stanieri
NCBI taxonomy Id: 292563
Other names: C. stanieri PCC 7202, Cyanobacterium stanieri PCC 7202, Synechococcus cedrorum CCAP 14792a (no longer available), Synechococcus cedrorum CCAP 14792b (no longer available), Synechococcus cedrorum M137/1a, Synechococcus cedrorum SAG 88.79, Synechococcus sp. ATCC 29140, Synechococcus sp. PCC 7202
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