STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ46758.1PFAM: GAF domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG2205 Osmosensitive K+ channel histidine kinase; InterProIPR016132:IPR005467:IPR001789:IPR003018:IPR 003661:IPR003594:IPR004358; KEGG: cyh:Cyan8802_2814 GAF sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; SMART: ATP-binding region ATPase domain protein; GAF domain protein; histidine kinase A domain protein; SPTR: Sensor protein. (743 aa)    
Predicted Functional Partners:
AFZ47413.1
PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000644:IPR003018:IPR000014:IPR001610:IPR 003661:IPR003594:IPR001789:IPR004358:IPR013767:IPR016132:I PR005467:IPR000700; KEGG: ava:Ava_1029 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; CBS domain containing protein; PAS fold domain pro [...]
 
 
0.923
AFZ47725.1
Integral membrane sensor hybrid histidine kinase; PFAM: Cache domain; HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358:IPR003660:IPR003661:IPR003594:IPR 001789:IPR005467; KEGG: cyn:Cyan7425_3552 cache sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; response regulator receiver; SMART: ATP-binding region ATPase dom [...]
 
 
0.913
AFZ46504.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterProIPR001789:IPR003661:IPR003594:IPR005467:IPR 004358; KEGG: ava:Ava_0649 response regulator receiver signal transduction histidine kinase; PFAM: response regulator receiver; histidine kinase A domain protein; ATP-binding region ATPase domain protein; SMART: response regulator receiver; histidine kinase A domain protein; ATP-binding region ATP [...]
 
0.898
AFZ46364.1
Multi-sensor hybrid histidine kinase; PFAM: CBS domain; Response regulator receiver domain; GAF domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000644:IPR003018:IPR013655:IPR013656:IPR 003661:IPR003594:IPR001789:IPR016132:IPR005467:IPR000014:I PR000700:IPR004358:IPR001610; KEGG: ava:Ava_4701 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; CB [...]
 
 
 
0.879
AFZ48090.1
Diguanylate cyclase with PAS/PAC and GAF sensors; PFAM: Protein kinase domain; GGDEF domain; GAF domain; NB-ARC domain; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG3899 ATPase; InterProIPR017442:IPR003018:IPR013767:IPR000160:IPR 000719:IPR000014:IPR000700:IPR020635:IPR002290; KEGG: mar:MAE_22800 serine/threonine kinase; PFAM: GGDEF domain containing protein; Serine/threonine-protein kinase-like domain; GAF domain protein; PAS fold domain protein; SMART: GGDEF domain containing protein; serine/threonine protein kinase; Tyrosine-protein kinase, catalytic domai [...]
 
 
 0.862
AFZ47818.1
PAS/PAC sensor hybrid histidine kinase; PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR000644:IPR013655:IPR013767:IPR 003661:IPR003594:IPR001789:IPR001610:IPR005467:IPR000700:I PR004358; KEGG: hmo:HM1_1611 sensor histidine kinase, putative; PFAM: ATP-binding region ATPase domain protein; PAS fold-3 domain protein; CBS domain containing protein; PAS fold domain protein; histidi [...]
 
 
 
0.854
AFZ48032.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR013655:IPR003018:IPR003661:IPR 003594:IPR001789:IPR001610:IPR005467:IPR000700:IPR004358; KEGG: gfo:GFO_0848 two-component system sensor histidine kinase/response regulator hybrid; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; GAF domain protein; response regulator rec [...]
 
 
 
0.854
AFZ46070.1
PFAM: GAF domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358:IPR000014:IPR003018:IPR003661:IPR 003594:IPR001789:IPR005467:IPR020606:IPR013656; KEGG: gvi:glr0718 two-component hybrid sensor and regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; PAS fold-4 domain protein; response regulator receiver; SMART: ATP-binding region ATPase [...]
 
 
 
0.853
AFZ47724.1
PFAM: Response regulator receiver domain; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789; KEGG: cyn:Cyan7425_0748 response regulator receiver protein; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver.
 
 0.851
AFZ47196.1
PFAM: Response regulator receiver domain; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789; KEGG: cyc:PCC7424_2789 response regulator receiver protein; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver protein.
 
 
 0.833
Your Current Organism:
Cyanobacterium stanieri
NCBI taxonomy Id: 292563
Other names: C. stanieri PCC 7202, Cyanobacterium stanieri PCC 7202, Synechococcus cedrorum CCAP 14792a (no longer available), Synechococcus cedrorum CCAP 14792b (no longer available), Synechococcus cedrorum M137/1a, Synechococcus cedrorum SAG 88.79, Synechococcus sp. ATCC 29140, Synechococcus sp. PCC 7202
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