STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AFZ47074.1Two component transcriptional regulator, winged helix family; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: cyc:PCC7424_1341 two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain-containing protein; SMART: response regulator receiver; SPTR: Two component transcriptional regulator, winged helix family. (250 aa)    
Predicted Functional Partners:
AFZ47413.1
PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000644:IPR003018:IPR000014:IPR001610:IPR 003661:IPR003594:IPR001789:IPR004358:IPR013767:IPR016132:I PR005467:IPR000700; KEGG: ava:Ava_1029 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; CBS domain containing protein; PAS fold domain pro [...]
 
 
 0.960
AFZ46070.1
PFAM: GAF domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358:IPR000014:IPR003018:IPR003661:IPR 003594:IPR001789:IPR005467:IPR020606:IPR013656; KEGG: gvi:glr0718 two-component hybrid sensor and regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; PAS fold-4 domain protein; response regulator receiver; SMART: ATP-binding region ATPase [...]
 
 
 0.945
AFZ47818.1
PAS/PAC sensor hybrid histidine kinase; PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR000644:IPR013655:IPR013767:IPR 003661:IPR003594:IPR001789:IPR001610:IPR005467:IPR000700:I PR004358; KEGG: hmo:HM1_1611 sensor histidine kinase, putative; PFAM: ATP-binding region ATPase domain protein; PAS fold-3 domain protein; CBS domain containing protein; PAS fold domain protein; histidi [...]
 
 
 0.943
AFZ48032.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR013655:IPR003018:IPR003661:IPR 003594:IPR001789:IPR001610:IPR005467:IPR000700:IPR004358; KEGG: gfo:GFO_0848 two-component system sensor histidine kinase/response regulator hybrid; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; GAF domain protein; response regulator rec [...]
 
 
 0.941
AFZ46364.1
Multi-sensor hybrid histidine kinase; PFAM: CBS domain; Response regulator receiver domain; GAF domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000644:IPR003018:IPR013655:IPR013656:IPR 003661:IPR003594:IPR001789:IPR016132:IPR005467:IPR000014:I PR000700:IPR004358:IPR001610; KEGG: ava:Ava_4701 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; CB [...]
 
 
0.929
AFZ47366.1
PFAM: HAMP domain; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR003660:IPR000014:IPR001610:IPR003661:IPR 003594:IPR001789:IPR004358:IPR013767:IPR013655:IPR005467:I PR000700:IPR000293; KEGG: integral membrane sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; PAS fold domain protein; PAS fold-3 d [...]
 
 
0.803
AFZ46012.1
Multi-sensor hybrid histidine kinase; PFAM: HAMP domain; Cache domain; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358:IPR000014:IPR001610:IPR003661:IPR 003594:IPR001789:IPR005467:IPR000700:IPR003660:IPR004010:I PR013655:IPR013656; KEGG: integral membrane sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; PAS [...]
 
 
0.802
AFZ46076.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR004358:IPR003661:IPR003594:IPR005467; KEGG: cyh:Cyan8802_3068 GAF sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Sensor protein.
  
   0.787
sasA
Histidine kinase; May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.
 
   0.777
AFZ47693.1
PFAM: Response regulator receiver domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: syp:SYNPCC7002_A1576 response regulator receiver domain-containing protein; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver domain protein.
  
   0.760
Your Current Organism:
Cyanobacterium stanieri
NCBI taxonomy Id: 292563
Other names: C. stanieri PCC 7202, Cyanobacterium stanieri PCC 7202, Synechococcus cedrorum CCAP 14792a (no longer available), Synechococcus cedrorum CCAP 14792b (no longer available), Synechococcus cedrorum M137/1a, Synechococcus cedrorum SAG 88.79, Synechococcus sp. ATCC 29140, Synechococcus sp. PCC 7202
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