STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa)    
Predicted Functional Partners:
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 
 0.990
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
  
 0.966
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
 0.953
trpE
Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...]
 
 
 0.951
AFZ46326.1
Para-aminobenzoate synthase, subunit I; PFAM: Glutamine amidotransferase class-I; chorismate binding enzyme; Anthranilate synthase component I, N terminal region; TIGRFAM: aminodeoxychorismate synthase, fungal clade; glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase; aminodeoxychorismate synthase, component I, bacterial clade; COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterProIPR000991:IPR006805:IPR015890:IPR017926:IPR 006220:IPR011702:IPR001317:IPR006221:IPR005802; KEGG: npu:Npun_R3717 para-aminobenzoate synthase, subunit I; [...]
 
 
 0.948
AFZ47431.1
Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
  
 
 0.946
AFZ46094.1
PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase; COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterProIPR006220:IPR011702:IPR001317:IPR017926:IPR 000991:IPR006221; KEGG: amr:AM1_1430 anthranilate synthase component II; PFAM: glutamine amidotransferase class-I; SPTR: Anthranilate synthase component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase.
 
 
 0.945
AFZ48213.1
Isochorismate synthase; PFAM: chorismate binding enzyme; TIGRFAM: isochorismate synthases; COGs: COG1169 Isochorismate synthase; InterPro IPR015890:IPR004561; KEGG: cyc:PCC7424_4752 isochorismate synthase; PFAM: Chorismate binding-like; SPTR: Isochorismate synthase; TIGRFAM: isochorismate synthase.
 
  
 0.891
AFZ47194.1
Arogenate dehydrogenase (NADP); PFAM: Prephenate dehydrogenase; COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099; KEGG: cyh:Cyan8802_0611 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; SPTR: Prephenate dehydrogenase.
  
 
 0.801
AFZ48498.1
Chorismate lyase; PFAM: Protein of unknown function (DUF98); COGs: COG3161 4-hydroxybenzoate synthetase (chorismate lyase); KEGG: cyc:PCC7424_0375 protein of unknown function DUF564; SPTR: Putative uncharacterized protein.
     
  0.800
Your Current Organism:
Cyanobacterium stanieri
NCBI taxonomy Id: 292563
Other names: C. stanieri PCC 7202, Cyanobacterium stanieri PCC 7202, Synechococcus cedrorum CCAP 14792a (no longer available), Synechococcus cedrorum CCAP 14792b (no longer available), Synechococcus cedrorum M137/1a, Synechococcus cedrorum SAG 88.79, Synechococcus sp. ATCC 29140, Synechococcus sp. PCC 7202
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