STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ47621.1PFAM: Response regulator receiver domain; Stage II sporulation protein E (SpoIIE); COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001789:IPR010822:IPR005829:IPR001932; KEGG: cyt:cce_3320 two-component response regulator; PFAM: Stage II sporulation protein E; response regulator receiver; SMART: response regulator receiver; protein phosphatase 2C domain protein; SPTR: Two-component response regulator. (374 aa)    
Predicted Functional Partners:
AFZ46223.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; GGDEF domain; FHA domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR000253:IPR000014:IPR000160:IPR001633:IPR 013767; KEGG: cyt:cce_2788 hypothetical protein; PFAM: EAL domain protein; Forkhead-associated protein; PAS fold domain protein; GGDEF domain containing protein; SMART: EAL domain protein; GGDEF domain containing protein; Forkhead-associated protein; PAS domain c [...]
  
  
 0.778
AFZ47873.1
COGs: COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase); KEGG: mar:MAE_59030 ATPase-like protein; SPTR: Similar to Q4BUT1_CROWT ATP-binding region.
 
 
 0.778
AFZ47440.1
Anti-sigma-factor antagonist; PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor; COGs: COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); InterPro IPR003658:IPR002645; KEGG: mar:MAE_59050 anti-sigma-factor antagonist; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; SPTR: Anti-sigma factor antagonist; TIGRFAM: anti-anti-sigma factor.
 
 
 0.758
AFZ47620.1
PFAM: Protein of unknown function (DUF752); COGs: COG4121 conserved hypothetical protein; InterPro IPR008471; KEGG: cyt:cce_2868 hypothetical protein; PFAM: protein of unknown function DUF752; SPTR: Putative uncharacterized protein.
       0.727
AFZ46309.1
Diguanylate cyclase with PAS/PAC sensor; PFAM: GGDEF domain; FHA domain; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000253:IPR000160:IPR000014; KEGG: cyc:PCC7424_3126 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: Forkhead-associated protein; GGDEF domain containing protein; SMART: GGDEF domain containing protein; Forkhead-associated protein; SPTR: Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S); TIGRFAM: diguanylate cyclase; PAS sensor protein.
  
  
 0.718
AFZ46539.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); PFAM: EAL domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR013655:IPR013767:IPR000160:IPR001633:IPR 000014:IPR000700:IPR001610:IPR003018; KEGG: cyc:PCC7424_1286 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain protein; GGDEF domain containing protein; PAS fold domain protein; PAS fold-3 domain protein; SMART: EAL domain protein; GGDEF [...]
  
  
 0.710
AFZ48513.1
Response regulator receiver protein; Controls heterocyst pattern formation.
  
    0.688
AFZ46070.1
PFAM: GAF domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358:IPR000014:IPR003018:IPR003661:IPR 003594:IPR001789:IPR005467:IPR020606:IPR013656; KEGG: gvi:glr0718 two-component hybrid sensor and regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; PAS fold-4 domain protein; response regulator receiver; SMART: ATP-binding region ATPase [...]
  
 0.671
AFZ47304.1
PFAM: Cellulose synthase; COGs: COG1215 Glycosyltransferase probably involved in cell wall biogenesis; InterPro IPR001173; KEGG: amr:AM1_4863 cellulose synthase catalytic subunit; PFAM: glycosyl transferase family 2; SPTR: Cellulose synthase superfamily.
  
 
 0.667
sasA
Histidine kinase; May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.
 
     0.610
Your Current Organism:
Cyanobacterium stanieri
NCBI taxonomy Id: 292563
Other names: C. stanieri PCC 7202, Cyanobacterium stanieri PCC 7202, Synechococcus cedrorum CCAP 14792a (no longer available), Synechococcus cedrorum CCAP 14792b (no longer available), Synechococcus cedrorum M137/1a, Synechococcus cedrorum SAG 88.79, Synechococcus sp. ATCC 29140, Synechococcus sp. PCC 7202
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