STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ48432.1Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; PFAM: C-terminal domain of 1-Cys peroxiredoxin; AhpC/TSA family; COGs: COG0450 Peroxiredoxin; InterPro IPR017936:IPR000866:IPR019479; KEGG: cyc:PCC7424_0090 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Peroxiredoxin-like; SPTR: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen. (195 aa)    
Predicted Functional Partners:
AFZ47186.1
KEGG: syn:slr1796 hypothetical protein; SPTR: Putative uncharacterized protein.
  
 0.919
AFZ46444.1
PFAM: Pyridine nucleotide-disulphide oxidoreductase; COGs: COG0492 Thioredoxin reductase; InterPro IPR013027:IPR000103; KEGG: syn:slr0600 hypothetical protein; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Slr0600 protein.
  
 
 0.816
AFZ48560.1
Redoxin domain protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.
   
 0.805
AFZ48433.1
PFAM: UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR014016:IPR014017:IPR000212; KEGG: cyh:Cyan8802_3290 UvrD/REP helicase; PFAM: UvrD/REP helicase; SPTR: Putative uncharacterized protein.
       0.580
AFZ47696.1
Ferritin Dps family protein; PFAM: Ferritin-like domain; COGs: COG0783 DNA-binding ferritin-like protein (oxidative damage protectant); InterPro IPR002177:IPR008331; KEGG: cyc:PCC7424_2510 DNA starvation/stationary phase protection protein Dps; PFAM: Ferritin Dps family protein; SPTR: Ferritin Dps family protein; Belongs to the Dps family.
  
  
 0.571
AFZ48431.1
Carbohydrate ABC transporter substrate-binding protein, CUT1 family; PFAM: Bacterial extracellular solute-binding protein; COGs: COG1653 ABC-type sugar transport system periplasmic component; InterPro IPR006059; KEGG: cyt:cce_3418 extracellular solute-binding protein; PFAM: extracellular solute-binding protein family 1; SPTR: Bacterial extracellular solute-binding protein, putative.
  
    0.551
AFZ47413.1
PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000644:IPR003018:IPR000014:IPR001610:IPR 003661:IPR003594:IPR001789:IPR004358:IPR013767:IPR016132:I PR005467:IPR000700; KEGG: ava:Ava_1029 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; CBS domain containing protein; PAS fold domain pro [...]
  
 
 0.518
AFZ47553.1
PFAM: Bacterial regulatory protein, arsR family; TIGRFAM: iron-sulfur cluster biosynthesis transcriptional regulator SufR; COGs: COG2345 transcriptional regulator protein; InterPro IPR001845:IPR014075; KEGG: cyh:Cyan8802_0425 putative transcriptional regulator; PFAM: regulatory protein ArsR; SPTR: Putative transcriptional regulator; TIGRFAM: iron-sulfur cluster biosynthesis transcriptional regulator SufR.
  
    0.512
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
   
 
 0.489
AFZ47234.1
PFAM: Metallo-beta-lactamase superfamily; Flavin reductase like domain; COGs: COG0426 flavoprotein; InterPro IPR008254:IPR002563; KEGG: cyh:Cyan8802_0685 flavin reductase domain protein FMN-binding; PFAM: flavin reductase domain protein FMN-binding; flavodoxin/nitric oxide synthase; SPTR: Flavin reductase domain protein FMN-binding.
  
  
 0.473
Your Current Organism:
Cyanobacterium stanieri
NCBI taxonomy Id: 292563
Other names: C. stanieri PCC 7202, Cyanobacterium stanieri PCC 7202, Synechococcus cedrorum CCAP 14792a (no longer available), Synechococcus cedrorum CCAP 14792b (no longer available), Synechococcus cedrorum M137/1a, Synechococcus cedrorum SAG 88.79, Synechococcus sp. ATCC 29140, Synechococcus sp. PCC 7202
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