STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFY30045.1Pyrimidine reductase, riboflavin biosynthesis; PFAM: RibD C-terminal domain. (231 aa)    
Predicted Functional Partners:
ribBA
GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
 
 0.896
AFY30044.1
PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: 6-pyruvoyl tetrahydropterin synthase/QueD family protein.
 
   
 0.846
AFY30287.1
PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit.
  
  
 0.774
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
       0.606
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
 
 0.564
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
  
 0.482
AFY27942.1
PFAM: Protein of unknown function (DUF3685).
  
     0.429
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.424
AFY29746.1
Putative transcriptional regulator; PFAM: Bacterial regulatory protein, arsR family.
  
  
 0.404
Your Current Organism:
Cyanobium gracile
NCBI taxonomy Id: 292564
Other names: C. gracile PCC 6307, Coccochloris peniocystis UTCC 70 (no longer available), Coccochloris peniocystis UTCC 71, Cyanobium gracile PCC 6307, Synechococcus sp. ATCC 27147, Synechococcus sp. PCC 6307
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