ARE59893.1 protein (Flavonifractor plautii) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

ARE59893.1

Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (55 aa)

Predicted Functional Partners:

ANU42691.1

0.774

ANU42692.1

0.673

ARE59894.1

0.449

ANU42690.1

0.408

Your Current Organism:

Flavonifractor plautii

NCBI taxonomy Id: 292800
Other names: ATCC 29863, ATCC 49531 [[Clostridium orbiscindens]], Bacillus plauti, CCUG 28093, Clostridium orbiscindens, DSM 4000, DSM 6740 [[Clostridium orbiscindens]], DSM 6749 [[Clostridium orbiscindens]], Eubacterium plautii, F. plautii, Fusobacterium plautii, Fusocillus plauti, Pseudoflavonifractor sp. YL31, Zuberella plauti, strain Prevot S1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANU42690.1	ANU42691.1	A4U99_17170	A4U99_17175	Recombinase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Plasmid recombination enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.846
ANU42690.1	ANU42692.1	A4U99_17170	A4U99_17180	Recombinase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Replication initiator protein A; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.656
ANU42690.1	ARE59893.1	A4U99_17170	A4U99_18800	Recombinase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.408
ANU42690.1	ARE59894.1	A4U99_17170	A4U99_18805	Recombinase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Conjugal transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.760
ANU42691.1	ANU42690.1	A4U99_17175	A4U99_17170	Plasmid recombination enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	Recombinase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.846
ANU42691.1	ANU42692.1	A4U99_17175	A4U99_17180	Plasmid recombination enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	Replication initiator protein A; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.912
ANU42691.1	ARE59893.1	A4U99_17175	A4U99_18800	Plasmid recombination enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.774
ANU42691.1	ARE59894.1	A4U99_17175	A4U99_18805	Plasmid recombination enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	Conjugal transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.894
ANU42692.1	ANU42690.1	A4U99_17180	A4U99_17170	Replication initiator protein A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Recombinase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.656
ANU42692.1	ANU42691.1	A4U99_17180	A4U99_17175	Replication initiator protein A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Plasmid recombination enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.912
ANU42692.1	ARE59893.1	A4U99_17180	A4U99_18800	Replication initiator protein A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.673
ANU42692.1	ARE59894.1	A4U99_17180	A4U99_18805	Replication initiator protein A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Conjugal transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.855
ARE59893.1	ANU42690.1	A4U99_18800	A4U99_17170	Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Recombinase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.408
ARE59893.1	ANU42691.1	A4U99_18800	A4U99_17175	Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Plasmid recombination enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.774
ARE59893.1	ANU42692.1	A4U99_18800	A4U99_17180	Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Replication initiator protein A; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.673
ARE59893.1	ARE59894.1	A4U99_18800	A4U99_18805	Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Conjugal transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.449
ARE59894.1	ANU42690.1	A4U99_18805	A4U99_17170	Conjugal transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Recombinase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.760
ARE59894.1	ANU42691.1	A4U99_18805	A4U99_17175	Conjugal transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Plasmid recombination enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.894
ARE59894.1	ANU42692.1	A4U99_18805	A4U99_17180	Conjugal transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Replication initiator protein A; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.855
ARE59894.1	ARE59893.1	A4U99_18805	A4U99_18800	Conjugal transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.449

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.847

expected number of edges:

36

PPI enrichment p-value:

0.998

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009401

Phosphoenolpyruvate-dependent sugar phosphotransferase system

11 of 117

1.18

1.76

1.31e-10

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0103111

D-glucosamine PTS permease activity

7 of 44

1.41

2.0

2.62e-07

GO:0008982

protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

10 of 91

1.25

1.89

9.53e-10

GO:0016740

Transferase activity

11 of 363

0.69

0.66

1.80e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

9 of 441

0.52

0.37

0.0113

GO:0005886

Plasma membrane

8 of 389

0.52

0.37

0.0145

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1608

Import into cell

11 of 52

1.54

3.32

1.57e-14

CL:1701

Mixed, incl. CAT RNA-binding domain, and PTS system fructose IIA component

4 of 5

2.11

2.63

4.56e-06

CL:1610

Import into cell

7 of 42

1.43

2.09

1.42e-07

CL:1612

Fructose and mannose metabolism, and PTS system sorbose subfamily IIB component

6 of 34

1.46

1.93

1.95e-06

CL:1644

Mixed, incl. PTS system sorbose-specific iic component, and PTS system sorbose subfamily IIB component

3 of 7

1.84

1.5

0.00082

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00051

Fructose and mannose metabolism

7 of 56

1.31

1.72

6.76e-07

map02060

Phosphotransferase system (PTS)

11 of 130

1.14

1.66

4.74e-11

map00520

Amino sugar and nucleotide sugar metabolism

7 of 78

1.16

1.36

3.84e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005887

Integral component of plasma membrane

4 of 40

1.21

0.89

0.0045

GOCC:0005886

Plasma membrane

11 of 305

0.77

8.54e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03609

PTS system sorbose-specific iic component

6 of 15

1.81

2.85

1.35e-07

PF03830

PTS system sorbose subfamily IIB component

3 of 15

1.51

0.84

0.0171

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004700

Phosphotransferase system, mannose/fructose/sorbose family, IIC subunit

6 of 15

1.81

2.69

4.10e-07

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