node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AWC09_02955 | ORV69724.1 | AWC09_02955 | AWC09_11960 | Hypothetical protein; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.853 |
AWC09_02955 | ORV70329.1 | AWC09_02955 | AWC09_10155 | Hypothetical protein; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.516 |
AWC09_02955 | ORV70464.1 | AWC09_02955 | AWC09_10170 | Hypothetical protein; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.981 |
AWC09_02955 | dut | AWC09_02955 | AWC09_05475 | Hypothetical protein; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.502 |
AWC09_02955 | glyA | AWC09_02955 | AWC09_02925 | Hypothetical protein; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.801 |
AWC09_02955 | thyA | AWC09_02955 | AWC09_05805 | Hypothetical protein; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.488 |
ORV69724.1 | AWC09_02955 | AWC09_11960 | AWC09_02955 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hypothetical protein; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.853 |
ORV69724.1 | ORV70329.1 | AWC09_11960 | AWC09_10155 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.706 |
ORV69724.1 | glyA | AWC09_11960 | AWC09_02925 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |
ORV69724.1 | thyA | AWC09_11960 | AWC09_05805 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.625 |
ORV70329.1 | AWC09_02955 | AWC09_10155 | AWC09_02955 | Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.516 |
ORV70329.1 | ORV69724.1 | AWC09_10155 | AWC09_11960 | Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.706 |
ORV70329.1 | ORV70330.1 | AWC09_10155 | AWC09_10160 | Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | NADP oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.613 |
ORV70329.1 | ORV70331.1 | AWC09_10155 | AWC09_10165 | Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.465 |
ORV70329.1 | ORV70464.1 | AWC09_10155 | AWC09_10170 | Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.478 |
ORV70329.1 | ORV70665.1 | AWC09_10155 | AWC09_09505 | Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.468 |
ORV70329.1 | ORV71378.1 | AWC09_10155 | AWC09_06780 | Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.453 |
ORV70329.1 | dut | AWC09_10155 | AWC09_05475 | Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.443 |
ORV70329.1 | glyA | AWC09_10155 | AWC09_02925 | Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.447 |
ORV70329.1 | thyA | AWC09_10155 | AWC09_05805 | Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.827 |