GAT88881.1 protein (Paenarthrobacter nicotinovorans)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

GAT88881.1

C4-dicarboxylate ABC transporter. (482 aa)

Predicted Functional Partners:

GAT88882.1

0.872

GAT87764.1

0.626

GAT87457.1

0.575

GAT86351.1

0.525

GAT88883.1

0.521

GAT87686.1

0.464

GAT88707.1

0.432

GAT89195.1

0.432

CVCC1112_6

0.432

GAT89541.1

0.425

Your Current Organism:

Paenarthrobacter nicotinovorans

NCBI taxonomy Id: 29320
Other names: ATCC 49919, Arthrobacter nicotinivorans, Arthrobacter nicotinovorans, Arthrobacter oxydans DSM 420, CIP 106990, DSM 420, IFO 15511, JCM 3874, LMG 16253, LMG:16253, NBRC 15511, P. nicotinovorans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVCC1112_6	GAT88881.1	CVCC1112_6	CVCC1112_3540	C4-dicarboxylate ABC transporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.	C4-dicarboxylate ABC transporter.	0.432
GAT86351.1	GAT88881.1	CVCC1112_1011	CVCC1112_3540	Sodium:proton antiporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.	C4-dicarboxylate ABC transporter.	0.525
GAT87457.1	GAT88881.1	CVCC1112_2116	CVCC1112_3540	Cation:proton antiporter.	C4-dicarboxylate ABC transporter.	0.575
GAT87686.1	GAT88881.1	CVCC1112_2345	CVCC1112_3540	Integrase.	C4-dicarboxylate ABC transporter.	0.464
GAT87764.1	GAT88881.1	CVCC1112_2423	CVCC1112_3540	Hypothetical protein.	C4-dicarboxylate ABC transporter.	0.626
GAT88707.1	GAT88881.1	CVCC1112_3366	CVCC1112_3540	C4-dicarboxylate ABC transporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.	C4-dicarboxylate ABC transporter.	0.432
GAT88881.1	CVCC1112_6	CVCC1112_3540	CVCC1112_6	C4-dicarboxylate ABC transporter.	C4-dicarboxylate ABC transporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.	0.432
GAT88881.1	GAT86351.1	CVCC1112_3540	CVCC1112_1011	C4-dicarboxylate ABC transporter.	Sodium:proton antiporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.	0.525
GAT88881.1	GAT87457.1	CVCC1112_3540	CVCC1112_2116	C4-dicarboxylate ABC transporter.	Cation:proton antiporter.	0.575
GAT88881.1	GAT87686.1	CVCC1112_3540	CVCC1112_2345	C4-dicarboxylate ABC transporter.	Integrase.	0.464
GAT88881.1	GAT87764.1	CVCC1112_3540	CVCC1112_2423	C4-dicarboxylate ABC transporter.	Hypothetical protein.	0.626
GAT88881.1	GAT88707.1	CVCC1112_3540	CVCC1112_3366	C4-dicarboxylate ABC transporter.	C4-dicarboxylate ABC transporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.	0.432
GAT88881.1	GAT88882.1	CVCC1112_3540	CVCC1112_3541	C4-dicarboxylate ABC transporter.	Methylitaconate delta2-delta3-isomerase.	0.872
GAT88881.1	GAT88883.1	CVCC1112_3540	CVCC1112_3542	C4-dicarboxylate ABC transporter.	LysR family transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.521
GAT88881.1	GAT89195.1	CVCC1112_3540	CVCC1112_3854	C4-dicarboxylate ABC transporter.	C4-dicarboxylate transporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.	0.432
GAT88881.1	GAT89541.1	CVCC1112_3540	CVCC1112_4200	C4-dicarboxylate ABC transporter.	Choline transporter; Belongs to the BCCT transporter (TC 2.A.15) family.	0.425
GAT88882.1	GAT88881.1	CVCC1112_3541	CVCC1112_3540	Methylitaconate delta2-delta3-isomerase.	C4-dicarboxylate ABC transporter.	0.872
GAT88882.1	GAT88883.1	CVCC1112_3541	CVCC1112_3542	Methylitaconate delta2-delta3-isomerase.	LysR family transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.602
GAT88883.1	GAT88881.1	CVCC1112_3542	CVCC1112_3540	LysR family transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	C4-dicarboxylate ABC transporter.	0.521
GAT88883.1	GAT88882.1	CVCC1112_3542	CVCC1112_3541	LysR family transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	Methylitaconate delta2-delta3-isomerase.	0.602

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Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.906

expected number of edges:

14

PPI enrichment p-value:

1.47e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0020037

Heme binding

7 of 46

1.78

3.23

3.43e-09

GO:0009055

Electron transfer activity

8 of 79

1.6

2.82

2.36e-09

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

2 of 10

1.9

0.71

0.0445

GO:0046872

Metal ion binding

8 of 631

0.7

0.52

0.0037

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

3 of 9

2.12

1.74

0.00041

GO:0070069

Cytochrome complex

2 of 3

2.42

1.27

0.0046

GO:0098803

Respiratory chain complex

2 of 6

2.12

1.16

0.0063

GO:0016020

Membrane

10 of 1353

0.47

0.36

0.0046

GO:0016021

Integral component of membrane

8 of 980

0.51

0.35

0.0182

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3160

Mixed, incl. Oxidative phosphorylation, and Immunoglobulin-like fold

9 of 45

1.9

4.74

7.78e-14

CL:3158

Mixed, incl. Oxidative phosphorylation, and Cytochrome c-like domain superfamily

10 of 59

1.83

4.69

5.27e-15

CL:3162

Mixed, incl. Oxidoreduction-driven active transmembrane transporter activity, and Cytochrome c-like domain

6 of 27

1.94

3.46

8.43e-09

CL:3229

Respiratory chain, and 4Fe-4S dicluster domain

3 of 5

2.38

2.16

8.02e-05

CL:3167

Oxidoreduction-driven active transmembrane transporter activity, and 4Fe-4S binding domain

2 of 7

2.05

0.9

0.0199

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

5 of 46

1.63

2.02

1.01e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

8 of 29

2.04

4.98

6.26e-13

GOCC:0070069

Cytochrome complex

3 of 5

2.38

2.09

0.00011

GOCC:0098803

Respiratory chain complex

3 of 12

1.99

1.63

0.00057

GOCC:0045278

Plasma membrane respiratory chain complex IV

2 of 2

2.6

1.4

0.0028

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0349

Heme

8 of 36

1.94

4.54

2.06e-12

KW-0679

Respiratory chain

3 of 5

2.38

2.32

3.86e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13442

Cytochrome C oxidase, cbb3-type, subunit III

3 of 6

2.3

1.68

0.00067

PF00034

Cytochrome c

3 of 12

1.99

1.4

0.0018

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009056

Cytochrome c-like domain

6 of 21

2.05

3.47

2.54e-08

IPR036909

Cytochrome c-like domain superfamily

6 of 24

1.99

3.39

2.54e-08

IPR008168

Cytochrome c, class IC

2 of 3

2.42

0.8

0.0346

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