node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDG5_0011 | CCDG5_0105 | CCDG5_0011 | CCDG5_0105 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Metal dependent phosphohydrolase; High confidence in function and specificity. | 0.900 |
CCDG5_0011 | CCDG5_0315 | CCDG5_0011 | CCDG5_0315 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Hypothetical protein; High confidence in function and specificity. | 0.941 |
CCDG5_0011 | thyX | CCDG5_0011 | CCDG5_1027 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.928 |
CCDG5_0105 | CCDG5_0011 | CCDG5_0105 | CCDG5_0011 | Metal dependent phosphohydrolase; High confidence in function and specificity. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.900 |
CCDG5_0105 | CCDG5_0315 | CCDG5_0105 | CCDG5_0315 | Metal dependent phosphohydrolase; High confidence in function and specificity. | Hypothetical protein; High confidence in function and specificity. | 0.900 |
CCDG5_0105 | thyX | CCDG5_0105 | CCDG5_1027 | Metal dependent phosphohydrolase; High confidence in function and specificity. | Hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.901 |
CCDG5_0315 | CCDG5_0011 | CCDG5_0315 | CCDG5_0011 | Hypothetical protein; High confidence in function and specificity. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.941 |
CCDG5_0315 | CCDG5_0105 | CCDG5_0315 | CCDG5_0105 | Hypothetical protein; High confidence in function and specificity. | Metal dependent phosphohydrolase; High confidence in function and specificity. | 0.900 |
CCDG5_0315 | thyX | CCDG5_0315 | CCDG5_1027 | Hypothetical protein; High confidence in function and specificity. | Hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.922 |
CCDG5_1402 | fhs | CCDG5_1402 | CCDG5_1275 | Homocysteine S-methyltransferase; High confidence in function and specificity. | Formate-tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | 0.972 |
CCDG5_1402 | fmt | CCDG5_1402 | CCDG5_1293 | Homocysteine S-methyltransferase; High confidence in function and specificity. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.958 |
CCDG5_1402 | folD | CCDG5_1402 | CCDG5_0608 | Homocysteine S-methyltransferase; High confidence in function and specificity. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.971 |
CCDG5_1402 | glyA | CCDG5_1402 | CCDG5_1952 | Homocysteine S-methyltransferase; High confidence in function and specificity. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.968 |
CCDG5_1402 | purH | CCDG5_1402 | CCDG5_0416 | Homocysteine S-methyltransferase; High confidence in function and specificity. | Bifunctional purine biosynthesis protein PurH; High confidence in function and specificity. | 0.951 |
CCDG5_1402 | purN | CCDG5_1402 | CCDG5_0414 | Homocysteine S-methyltransferase; High confidence in function and specificity. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.952 |
CCDG5_1402 | thyX | CCDG5_1402 | CCDG5_1027 | Homocysteine S-methyltransferase; High confidence in function and specificity. | Hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.932 |
fhs | CCDG5_1402 | CCDG5_1275 | CCDG5_1402 | Formate-tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Homocysteine S-methyltransferase; High confidence in function and specificity. | 0.972 |
fhs | fmt | CCDG5_1275 | CCDG5_1293 | Formate-tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.549 |
fhs | folD | CCDG5_1275 | CCDG5_0608 | Formate-tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.997 |
fhs | glyA | CCDG5_1275 | CCDG5_1952 | Formate-tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.981 |