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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spoIVAStage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. (491 aa)    
Predicted Functional Partners:
OPJ56936.1
Hypothetical protein; Transcription termination factor Rho.
  
  
 0.907
spoIIID
Stage III sporulation protein D.
  
  
 0.889
OPJ55597.1
Stage II sporulation protein SpoIIP.
 
   
 0.872
OPJ54808.1
Stage II sporulation protein SpoIIR.
  
   
 0.867
OPJ56939.1
Stage III sporulation protein AC/AD protein family protein.
  
    0.865
spo0A_1
Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.863
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.858
OPJ56942.1
Hypothetical protein.
  
  
 0.855
gpr
Germination protease precursor; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family.
  
   
 0.853
lytB_2
Amidase enhancer precursor.
  
  
 0.831
Your Current Organism:
Clostridium thermoalcaliphilum
NCBI taxonomy Id: 29349
Other names: ATCC 51508, CIP 105528, DSM 7309, [. thermoalcaliphilum, [Clostridium] thermoalcaliphilum, strain JW/YL23-2
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