STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
OPJ57056.1Putative GTP cyclohydrolase 1 type 2; Belongs to the GTP cyclohydrolase I type 2/NIF3 family. (366 aa)    
Predicted Functional Partners:
trmK
tRNA (adenine(22)-N(1))-methyltransferase.
  
 0.992
pyk
Pyruvate kinase; Belongs to the pyruvate kinase family.
   
  0.922
ribBA
Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
    
  0.902
folE
GTP cyclohydrolase 1.
    
 0.896
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.
    
  0.869
relA
GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
   
 
  0.822
OPJ57073.1
6-pyruvoyl tetrahydropterin synthase.
    
 0.817
rnhA
Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
  
  
 0.723
OPJ57054.1
Hypothetical protein.
       0.639
nfo_1
Putative endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
     
 0.634
Your Current Organism:
Clostridium thermoalcaliphilum
NCBI taxonomy Id: 29349
Other names: ATCC 51508, CIP 105528, DSM 7309, [. thermoalcaliphilum, [Clostridium] thermoalcaliphilum, strain JW/YL23-2
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