| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cobS | cobT | CLOTH_09670 | CLOTH_11800 | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.976 |
| cobS | pspA_1 | CLOTH_09670 | CLOTH_04860 | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | Phosphoserine phosphatase 1; Belongs to the phosphoglycerate mutase family. | 0.840 |
| cobT | cobS | CLOTH_11800 | CLOTH_09670 | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.976 |
| cobT | pspA_1 | CLOTH_11800 | CLOTH_04860 | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | Phosphoserine phosphatase 1; Belongs to the phosphoglycerate mutase family. | 0.746 |
| glyA | pgk/tpi | CLOTH_00660 | CLOTH_08370 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Bifunctional PGK/TIM; Belongs to the phosphoglycerate kinase family. | 0.605 |
| glyA | pspA_1 | CLOTH_00660 | CLOTH_04860 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine phosphatase 1; Belongs to the phosphoglycerate mutase family. | 0.885 |
| glyA | sdhA | CLOTH_00660 | CLOTH_13300 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase, alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.958 |
| glyA | sdhB | CLOTH_00660 | CLOTH_13290 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase, beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.961 |
| glyA | tdcB | CLOTH_00660 | CLOTH_13270 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-threonine dehydratase catabolic TdcB. | 0.891 |
| gpmI | pgk/tpi | CLOTH_08390 | CLOTH_08370 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | Bifunctional PGK/TIM; Belongs to the phosphoglycerate kinase family. | 0.997 |
| gpmI | pspA_1 | CLOTH_08390 | CLOTH_04860 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | Phosphoserine phosphatase 1; Belongs to the phosphoglycerate mutase family. | 0.718 |
| pgk/tpi | glyA | CLOTH_08370 | CLOTH_00660 | Bifunctional PGK/TIM; Belongs to the phosphoglycerate kinase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.605 |
| pgk/tpi | gpmI | CLOTH_08370 | CLOTH_08390 | Bifunctional PGK/TIM; Belongs to the phosphoglycerate kinase family. | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | 0.997 |
| pgk/tpi | pspA_1 | CLOTH_08370 | CLOTH_04860 | Bifunctional PGK/TIM; Belongs to the phosphoglycerate kinase family. | Phosphoserine phosphatase 1; Belongs to the phosphoglycerate mutase family. | 0.721 |
| plsC | pspA_1 | CLOTH_04830 | CLOTH_04860 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. | Phosphoserine phosphatase 1; Belongs to the phosphoglycerate mutase family. | 0.676 |
| plsC | ybbH_1 | CLOTH_04830 | CLOTH_04870 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. | Putative HTH-type transcriptional regulator YbbH. | 0.529 |
| pspA_1 | cobS | CLOTH_04860 | CLOTH_09670 | Phosphoserine phosphatase 1; Belongs to the phosphoglycerate mutase family. | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.840 |
| pspA_1 | cobT | CLOTH_04860 | CLOTH_11800 | Phosphoserine phosphatase 1; Belongs to the phosphoglycerate mutase family. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.746 |
| pspA_1 | glyA | CLOTH_04860 | CLOTH_00660 | Phosphoserine phosphatase 1; Belongs to the phosphoglycerate mutase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.885 |
| pspA_1 | gpmI | CLOTH_04860 | CLOTH_08390 | Phosphoserine phosphatase 1; Belongs to the phosphoglycerate mutase family. | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | 0.718 |