| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| OPJ55134.1 | birA | CLOTH_16320 | CLOTH_19460 | Putative epimerase/dehydratase. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.435 |
| OPJ55134.1 | glyA | CLOTH_16320 | CLOTH_00660 | Putative epimerase/dehydratase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.475 |
| OPJ55134.1 | metK_1 | CLOTH_16320 | CLOTH_05970 | Putative epimerase/dehydratase. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.932 |
| OPJ55134.1 | ribBA | CLOTH_16320 | CLOTH_14300 | Putative epimerase/dehydratase. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.597 |
| OPJ56192.1 | dpnA | CLOTH_05960 | CLOTH_05980 | Hypothetical protein. | Modification methylase DpnIIB; Belongs to the N(4)/N(6)-methyltransferase family. | 0.952 |
| OPJ56192.1 | metK_1 | CLOTH_05960 | CLOTH_05970 | Hypothetical protein. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.741 |
| birA | OPJ55134.1 | CLOTH_19460 | CLOTH_16320 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Putative epimerase/dehydratase. | 0.435 |
| birA | dpnA | CLOTH_19460 | CLOTH_05980 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Modification methylase DpnIIB; Belongs to the N(4)/N(6)-methyltransferase family. | 0.437 |
| birA | guaA | CLOTH_19460 | CLOTH_11700 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.809 |
| birA | metK_1 | CLOTH_19460 | CLOTH_05970 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.679 |
| birA | ribBA | CLOTH_19460 | CLOTH_14300 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.764 |
| birA | ribH | CLOTH_19460 | CLOTH_14310 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.417 |
| dpnA | OPJ56192.1 | CLOTH_05980 | CLOTH_05960 | Modification methylase DpnIIB; Belongs to the N(4)/N(6)-methyltransferase family. | Hypothetical protein. | 0.952 |
| dpnA | birA | CLOTH_05980 | CLOTH_19460 | Modification methylase DpnIIB; Belongs to the N(4)/N(6)-methyltransferase family. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.437 |
| dpnA | guaA | CLOTH_05980 | CLOTH_11700 | Modification methylase DpnIIB; Belongs to the N(4)/N(6)-methyltransferase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.535 |
| dpnA | metK_1 | CLOTH_05980 | CLOTH_05970 | Modification methylase DpnIIB; Belongs to the N(4)/N(6)-methyltransferase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.807 |
| glyA | OPJ55134.1 | CLOTH_00660 | CLOTH_16320 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative epimerase/dehydratase. | 0.475 |
| glyA | guaA | CLOTH_00660 | CLOTH_11700 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.888 |
| glyA | mdeA | CLOTH_00660 | CLOTH_08320 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methionine gamma-lyase. | 0.537 |
| glyA | metK_1 | CLOTH_00660 | CLOTH_05970 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.631 |