| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| OPJ55948.1 | OPJ56309.1 | CLOTH_11260 | CLOTH_07130 | Cobalt-dependent inorganic pyrophosphatase. | Hypothetical protein; Putative metallophosphoesterase MG207 homolog. | 0.420 |
| OPJ55948.1 | guaA | CLOTH_11260 | CLOTH_11700 | Cobalt-dependent inorganic pyrophosphatase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.944 |
| OPJ55948.1 | guaB | CLOTH_11260 | CLOTH_11710 | Cobalt-dependent inorganic pyrophosphatase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.929 |
| OPJ55948.1 | purA | CLOTH_11260 | CLOTH_14890 | Cobalt-dependent inorganic pyrophosphatase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.935 |
| OPJ55948.1 | purH | CLOTH_11260 | CLOTH_11640 | Cobalt-dependent inorganic pyrophosphatase. | Bifunctional purine biosynthesis protein PurH. | 0.850 |
| OPJ55948.1 | racE | CLOTH_11260 | CLOTH_19310 | Cobalt-dependent inorganic pyrophosphatase. | Glutamate racemase 1; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.538 |
| OPJ55948.1 | rph | CLOTH_11260 | CLOTH_07120 | Cobalt-dependent inorganic pyrophosphatase. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.928 |
| OPJ56309.1 | OPJ55948.1 | CLOTH_07130 | CLOTH_11260 | Hypothetical protein; Putative metallophosphoesterase MG207 homolog. | Cobalt-dependent inorganic pyrophosphatase. | 0.420 |
| OPJ56309.1 | rph | CLOTH_07130 | CLOTH_07120 | Hypothetical protein; Putative metallophosphoesterase MG207 homolog. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.938 |
| guaA | OPJ55948.1 | CLOTH_11700 | CLOTH_11260 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Cobalt-dependent inorganic pyrophosphatase. | 0.944 |
| guaA | guaB | CLOTH_11700 | CLOTH_11710 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | purA | CLOTH_11700 | CLOTH_14890 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.959 |
| guaA | purH | CLOTH_11700 | CLOTH_11640 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Bifunctional purine biosynthesis protein PurH. | 0.965 |
| guaA | racE | CLOTH_11700 | CLOTH_19310 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Glutamate racemase 1; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.712 |
| guaA | rph | CLOTH_11700 | CLOTH_07120 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.983 |
| guaA | rpsD | CLOTH_11700 | CLOTH_18310 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. | 0.836 |
| guaA | rpsK | CLOTH_11700 | CLOTH_18320 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. | 0.823 |
| guaB | OPJ55948.1 | CLOTH_11710 | CLOTH_11260 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Cobalt-dependent inorganic pyrophosphatase. | 0.929 |
| guaB | guaA | CLOTH_11710 | CLOTH_11700 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | purA | CLOTH_11710 | CLOTH_14890 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.953 |
