clpP protein (Clostridium thermoalcaliphilum)

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clpP

ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (194 aa)

Predicted Functional Partners:

clpX

0.996

clpC

0.874

clpB

0.849

tig

0.716

polA_1

0.698

groS

0.683

hndC_1

0.682

hndC_2

0.682

OPJ57185.1

0.668

clpP1_2

0.664

Your Current Organism:

Clostridium thermoalcaliphilum

NCBI taxonomy Id: 29349
Other names: ATCC 51508, CIP 105528, DSM 7309, [. thermoalcaliphilum, [Clostridium] thermoalcaliphilum, strain JW/YL23-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OPJ57185.1	clpP	CLOTH_04680	CLOTH_07170	Putative redox-active protein.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.668
OPJ57185.1	clpP1_2	CLOTH_04680	CLOTH_10700	Putative redox-active protein.	ATP-dependent Clp protease proteolytic subunit 1; Belongs to the peptidase S14 family.	0.668
OPJ57185.1	clpX	CLOTH_04680	CLOTH_07180	Putative redox-active protein.	ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	0.817
clpB	clpP	CLOTH_10060	CLOTH_07170	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.849
clpB	clpP1_2	CLOTH_10060	CLOTH_10700	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease proteolytic subunit 1; Belongs to the peptidase S14 family.	0.849
clpB	clpX	CLOTH_10060	CLOTH_07180	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	0.414
clpB	groS	CLOTH_10060	CLOTH_11770	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.709
clpC	clpP	CLOTH_16500	CLOTH_07170	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.874
clpC	clpP1_2	CLOTH_16500	CLOTH_10700	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease proteolytic subunit 1; Belongs to the peptidase S14 family.	0.868
clpC	clpX	CLOTH_16500	CLOTH_07180	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	0.414
clpC	groS	CLOTH_16500	CLOTH_11770	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.709
clpP	OPJ57185.1	CLOTH_07170	CLOTH_04680	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Putative redox-active protein.	0.668
clpP	clpB	CLOTH_07170	CLOTH_10060	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.849
clpP	clpC	CLOTH_07170	CLOTH_16500	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Negative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family.	0.874
clpP	clpP1_2	CLOTH_07170	CLOTH_10700	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	ATP-dependent Clp protease proteolytic subunit 1; Belongs to the peptidase S14 family.	0.664
clpP	clpX	CLOTH_07170	CLOTH_07180	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	0.996
clpP	groS	CLOTH_07170	CLOTH_11770	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.683
clpP	hndC_1	CLOTH_07170	CLOTH_04660	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	NADP-reducing hydrogenase subunit HndC.	0.682
clpP	hndC_2	CLOTH_07170	CLOTH_07660	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	NADP-reducing hydrogenase subunit HndC.	0.682
clpP	polA_1	CLOTH_07170	CLOTH_12690	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.698

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