purN protein (Clostridium thermoalcaliphilum)

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purN

Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (197 aa)

Predicted Functional Partners:

purL

0.999

purD

0.999

purH

0.999

purM

0.999

purF

0.998

purC

0.998

purK

0.994

purE_1

0.991

fhs

0.977

glyA

0.974

Your Current Organism:

Clostridium thermoalcaliphilum

NCBI taxonomy Id: 29349
Other names: ATCC 51508, CIP 105528, DSM 7309, [. thermoalcaliphilum, [Clostridium] thermoalcaliphilum, strain JW/YL23-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
fhs	glyA	CLOTH_16610	CLOTH_00660	Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.985
fhs	purC	CLOTH_16610	CLOTH_11680	Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.	0.782
fhs	purD	CLOTH_16610	CLOTH_11630	Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	Phosphoribosylamine--glycine ligase; Belongs to the GARS family.	0.810
fhs	purE_1	CLOTH_16610	CLOTH_07640	Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.717
fhs	purF	CLOTH_16610	CLOTH_11670	Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.	0.692
fhs	purH	CLOTH_16610	CLOTH_11640	Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	Bifunctional purine biosynthesis protein PurH.	0.974
fhs	purK	CLOTH_16610	CLOTH_07630	Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).	0.463
fhs	purL	CLOTH_16610	CLOTH_11620	Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	Phosphoribosylformylglycinamidine synthase 2.	0.937
fhs	purM	CLOTH_16610	CLOTH_11660	Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	Phosphoribosylformylglycinamidine cyclo-ligase.	0.485
fhs	purN	CLOTH_16610	CLOTH_11650	Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.	0.977
glyA	fhs	CLOTH_00660	CLOTH_16610	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	0.985
glyA	purC	CLOTH_00660	CLOTH_11680	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.	0.684
glyA	purD	CLOTH_00660	CLOTH_11630	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoribosylamine--glycine ligase; Belongs to the GARS family.	0.851
glyA	purF	CLOTH_00660	CLOTH_11670	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.	0.743
glyA	purH	CLOTH_00660	CLOTH_11640	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Bifunctional purine biosynthesis protein PurH.	0.989
glyA	purK	CLOTH_00660	CLOTH_07630	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).	0.438
glyA	purL	CLOTH_00660	CLOTH_11620	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoribosylformylglycinamidine synthase 2.	0.973
glyA	purM	CLOTH_00660	CLOTH_11660	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoribosylformylglycinamidine cyclo-ligase.	0.670
glyA	purN	CLOTH_00660	CLOTH_11650	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.	0.974
purC	fhs	CLOTH_11680	CLOTH_16610	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.	Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	0.782

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