guaA protein (Clostridium thermoalcaliphilum)

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Score

guaA

GMP synthase; Catalyzes the synthesis of GMP from XMP. (511 aa)

Predicted Functional Partners:

purL

0.999

guaB

0.999

argS

0.999

rplK

0.999

map

0.998

pyrG

0.995

xpt

0.994

apt

0.990

lysS

0.989

gmk

0.988

Your Current Organism:

Clostridium thermoalcaliphilum

NCBI taxonomy Id: 29349
Other names: ATCC 51508, CIP 105528, DSM 7309, [. thermoalcaliphilum, [Clostridium] thermoalcaliphilum, strain JW/YL23-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
apt	gmk	CLOTH_00540	CLOTH_01830	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.944
apt	guaA	CLOTH_00540	CLOTH_11700	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.990
apt	guaB	CLOTH_00540	CLOTH_11710	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.481
apt	purL	CLOTH_00540	CLOTH_11620	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Phosphoribosylformylglycinamidine synthase 2.	0.756
apt	pyrG	CLOTH_00540	CLOTH_17630	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.437
apt	xpt	CLOTH_00540	CLOTH_19090	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.945
argS	gmk	CLOTH_16700	CLOTH_01830	arginine--tRNA ligase.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.404
argS	guaA	CLOTH_16700	CLOTH_11700	arginine--tRNA ligase.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.999
argS	lysS	CLOTH_16700	CLOTH_19520	arginine--tRNA ligase.	lysine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family.	0.947
argS	purL	CLOTH_16700	CLOTH_11620	arginine--tRNA ligase.	Phosphoribosylformylglycinamidine synthase 2.	0.770
argS	pyrG	CLOTH_16700	CLOTH_17630	arginine--tRNA ligase.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.828
argS	rplK	CLOTH_16700	CLOTH_18710	arginine--tRNA ligase.	50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.642
gmk	apt	CLOTH_01830	CLOTH_00540	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.944
gmk	argS	CLOTH_01830	CLOTH_16700	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	arginine--tRNA ligase.	0.404
gmk	guaA	CLOTH_01830	CLOTH_11700	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.988
gmk	guaB	CLOTH_01830	CLOTH_11710	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.562
gmk	purL	CLOTH_01830	CLOTH_11620	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Phosphoribosylformylglycinamidine synthase 2.	0.768
gmk	pyrG	CLOTH_01830	CLOTH_17630	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.602
gmk	xpt	CLOTH_01830	CLOTH_19090	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.957
guaA	apt	CLOTH_11700	CLOTH_00540	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.990