guaA protein (Clostridium thermoalcaliphilum)

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Score

guaA

GMP synthase; Catalyzes the synthesis of GMP from XMP. (511 aa)

Predicted Functional Partners:

guaB

0.999

purL

0.993

xpt

0.984

rph

0.983

gmk

0.980

argS

0.978

pyrG

0.977

pyrD

0.975

lysS

0.966

purH

0.965

Your Current Organism:

Clostridium thermoalcaliphilum

NCBI taxonomy Id: 29349
Other names: ATCC 51508, CIP 105528, DSM 7309, [. thermoalcaliphilum, [Clostridium] thermoalcaliphilum, strain JW/YL23-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
argS	gmk	CLOTH_16700	CLOTH_01830	arginine--tRNA ligase.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.419
argS	guaA	CLOTH_16700	CLOTH_11700	arginine--tRNA ligase.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.978
argS	lysS	CLOTH_16700	CLOTH_19520	arginine--tRNA ligase.	lysine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family.	0.982
argS	purL	CLOTH_16700	CLOTH_11620	arginine--tRNA ligase.	Phosphoribosylformylglycinamidine synthase 2.	0.804
argS	pyrG	CLOTH_16700	CLOTH_17630	arginine--tRNA ligase.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.833
argS	rph	CLOTH_16700	CLOTH_07120	arginine--tRNA ligase.	Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.	0.450
gmk	argS	CLOTH_01830	CLOTH_16700	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	arginine--tRNA ligase.	0.419
gmk	guaA	CLOTH_01830	CLOTH_11700	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.980
gmk	guaB	CLOTH_01830	CLOTH_11710	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.570
gmk	purL	CLOTH_01830	CLOTH_11620	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Phosphoribosylformylglycinamidine synthase 2.	0.794
gmk	pyrG	CLOTH_01830	CLOTH_17630	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.486
gmk	rph	CLOTH_01830	CLOTH_07120	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.	0.730
gmk	xpt	CLOTH_01830	CLOTH_19090	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.954
guaA	argS	CLOTH_11700	CLOTH_16700	GMP synthase; Catalyzes the synthesis of GMP from XMP.	arginine--tRNA ligase.	0.978
guaA	gmk	CLOTH_11700	CLOTH_01830	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.980
guaA	guaB	CLOTH_11700	CLOTH_11710	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.999
guaA	lysS	CLOTH_11700	CLOTH_19520	GMP synthase; Catalyzes the synthesis of GMP from XMP.	lysine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family.	0.966
guaA	purH	CLOTH_11700	CLOTH_11640	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Bifunctional purine biosynthesis protein PurH.	0.965
guaA	purL	CLOTH_11700	CLOTH_11620	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Phosphoribosylformylglycinamidine synthase 2.	0.993
guaA	pyrD	CLOTH_11700	CLOTH_11860	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Dihydroorotate dehydrogenase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate.	0.975