guaB protein (Clostridium thermoalcaliphilum)

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guaB

Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)

Predicted Functional Partners:

guaA

0.999

purH

0.989

purA

0.953

rph

0.946

OPJ55948.1

0.929

purL

0.918

purK

0.914

surE

0.909

ribBA

0.883

purF

0.838

Your Current Organism:

Clostridium thermoalcaliphilum

NCBI taxonomy Id: 29349
Other names: ATCC 51508, CIP 105528, DSM 7309, [. thermoalcaliphilum, [Clostridium] thermoalcaliphilum, strain JW/YL23-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OPJ55948.1	guaA	CLOTH_11260	CLOTH_11700	Cobalt-dependent inorganic pyrophosphatase.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.944
OPJ55948.1	guaB	CLOTH_11260	CLOTH_11710	Cobalt-dependent inorganic pyrophosphatase.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.929
OPJ55948.1	purA	CLOTH_11260	CLOTH_14890	Cobalt-dependent inorganic pyrophosphatase.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.935
OPJ55948.1	purH	CLOTH_11260	CLOTH_11640	Cobalt-dependent inorganic pyrophosphatase.	Bifunctional purine biosynthesis protein PurH.	0.850
OPJ55948.1	purL	CLOTH_11260	CLOTH_11620	Cobalt-dependent inorganic pyrophosphatase.	Phosphoribosylformylglycinamidine synthase 2.	0.647
OPJ55948.1	rph	CLOTH_11260	CLOTH_07120	Cobalt-dependent inorganic pyrophosphatase.	Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.	0.928
OPJ55948.1	surE	CLOTH_11260	CLOTH_04920	Cobalt-dependent inorganic pyrophosphatase.	5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.843
guaA	OPJ55948.1	CLOTH_11700	CLOTH_11260	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Cobalt-dependent inorganic pyrophosphatase.	0.944
guaA	guaB	CLOTH_11700	CLOTH_11710	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.999
guaA	purA	CLOTH_11700	CLOTH_14890	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.959
guaA	purF	CLOTH_11700	CLOTH_11670	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.	0.922
guaA	purH	CLOTH_11700	CLOTH_11640	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Bifunctional purine biosynthesis protein PurH.	0.965
guaA	purK	CLOTH_11700	CLOTH_07630	GMP synthase; Catalyzes the synthesis of GMP from XMP.	N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).	0.783
guaA	purL	CLOTH_11700	CLOTH_11620	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Phosphoribosylformylglycinamidine synthase 2.	0.993
guaA	ribBA	CLOTH_11700	CLOTH_14300	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.824
guaA	rph	CLOTH_11700	CLOTH_07120	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.	0.983
guaA	surE	CLOTH_11700	CLOTH_04920	GMP synthase; Catalyzes the synthesis of GMP from XMP.	5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.962
guaB	OPJ55948.1	CLOTH_11710	CLOTH_11260	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	Cobalt-dependent inorganic pyrophosphatase.	0.929
guaB	guaA	CLOTH_11710	CLOTH_11700	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.999
guaB	purA	CLOTH_11710	CLOTH_14890	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.953

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