upp protein (Clostridium thermoalcaliphilum)

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upp

Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)

Predicted Functional Partners:

udk

0.997

thrZ_2

0.984

pyrH

0.977

guaA

0.976

pyrF

0.966

ywlF

0.958

pdp

0.949

pyrR

0.915

surE

0.897

glyA

0.836

Your Current Organism:

Clostridium thermoalcaliphilum

NCBI taxonomy Id: 29349
Other names: ATCC 51508, CIP 105528, DSM 7309, [. thermoalcaliphilum, [Clostridium] thermoalcaliphilum, strain JW/YL23-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
glyA	guaA	CLOTH_00660	CLOTH_11700	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.888
glyA	pdp	CLOTH_00660	CLOTH_02510	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Pyrimidine-nucleoside phosphorylase.	0.638
glyA	pyrF	CLOTH_00660	CLOTH_11880	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily.	0.448
glyA	thrZ_2	CLOTH_00660	CLOTH_09810	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	threonine--tRNA ligase 2.	0.475
glyA	upp	CLOTH_00660	CLOTH_15740	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.	0.836
glyA	ywlF	CLOTH_00660	CLOTH_15750	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Putative sugar phosphate isomerase YwlF.	0.954
guaA	glyA	CLOTH_11700	CLOTH_00660	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.888
guaA	pdp	CLOTH_11700	CLOTH_02510	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Pyrimidine-nucleoside phosphorylase.	0.700
guaA	pyrF	CLOTH_11700	CLOTH_11880	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily.	0.805
guaA	pyrH	CLOTH_11700	CLOTH_04040	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.869
guaA	pyrR	CLOTH_11700	CLOTH_01760	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Bifunctional protein PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.	0.684
guaA	surE	CLOTH_11700	CLOTH_04920	GMP synthase; Catalyzes the synthesis of GMP from XMP.	5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.976
guaA	thrZ_2	CLOTH_11700	CLOTH_09810	GMP synthase; Catalyzes the synthesis of GMP from XMP.	threonine--tRNA ligase 2.	0.872
guaA	udk	CLOTH_11700	CLOTH_02550	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Uridine kinase.	0.444
guaA	upp	CLOTH_11700	CLOTH_15740	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.	0.976
guaA	ywlF	CLOTH_11700	CLOTH_15750	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Putative sugar phosphate isomerase YwlF.	0.479
pdp	glyA	CLOTH_02510	CLOTH_00660	Pyrimidine-nucleoside phosphorylase.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.638
pdp	guaA	CLOTH_02510	CLOTH_11700	Pyrimidine-nucleoside phosphorylase.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.700
pdp	pyrR	CLOTH_02510	CLOTH_01760	Pyrimidine-nucleoside phosphorylase.	Bifunctional protein PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.	0.905
pdp	surE	CLOTH_02510	CLOTH_04920	Pyrimidine-nucleoside phosphorylase.	5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.909

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