thiC protein (Clostridium thermoalcaliphilum)

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thiC

Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (437 aa)

Predicted Functional Partners:

thiD

0.998

thiG

0.991

OPJ55190.1

0.982

thiE

0.979

tenI

0.975

thiH_1

0.946

moeB

0.924

purM

0.868

thiH_2

0.768

OPJ55516.1

0.642

Your Current Organism:

Clostridium thermoalcaliphilum

NCBI taxonomy Id: 29349
Other names: ATCC 51508, CIP 105528, DSM 7309, [. thermoalcaliphilum, [Clostridium] thermoalcaliphilum, strain JW/YL23-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OPJ55190.1	moeB	CLOTH_16900	CLOTH_16890	Sulfur carrier protein ThiS.	Molybdopterin-synthase adenylyltransferase.	0.991
OPJ55190.1	tenI	CLOTH_16900	CLOTH_16850	Sulfur carrier protein ThiS.	Regulatory protein TenI; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).	0.962
OPJ55190.1	thiC	CLOTH_16900	CLOTH_16860	Sulfur carrier protein ThiS.	Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	0.982
OPJ55190.1	thiD	CLOTH_16900	CLOTH_16840	Sulfur carrier protein ThiS.	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.	0.975
OPJ55190.1	thiE	CLOTH_16900	CLOTH_16830	Sulfur carrier protein ThiS.	Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.961
OPJ55190.1	thiG	CLOTH_16900	CLOTH_16880	Sulfur carrier protein ThiS.	Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.	0.998
OPJ55190.1	thiH_1	CLOTH_16900	CLOTH_16870	Sulfur carrier protein ThiS.	2-iminoacetate synthase.	0.937
OPJ55190.1	thiH_2	CLOTH_16900	CLOTH_17850	Sulfur carrier protein ThiS.	2-iminoacetate synthase.	0.748
OPJ55516.1	thiC	CLOTH_12740	CLOTH_16860	Hypothetical protein.	Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	0.642
moeB	OPJ55190.1	CLOTH_16890	CLOTH_16900	Molybdopterin-synthase adenylyltransferase.	Sulfur carrier protein ThiS.	0.991
moeB	tenI	CLOTH_16890	CLOTH_16850	Molybdopterin-synthase adenylyltransferase.	Regulatory protein TenI; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).	0.931
moeB	thiC	CLOTH_16890	CLOTH_16860	Molybdopterin-synthase adenylyltransferase.	Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	0.924
moeB	thiD	CLOTH_16890	CLOTH_16840	Molybdopterin-synthase adenylyltransferase.	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.	0.884
moeB	thiE	CLOTH_16890	CLOTH_16830	Molybdopterin-synthase adenylyltransferase.	Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.963
moeB	thiG	CLOTH_16890	CLOTH_16880	Molybdopterin-synthase adenylyltransferase.	Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.	0.987
moeB	thiH_1	CLOTH_16890	CLOTH_16870	Molybdopterin-synthase adenylyltransferase.	2-iminoacetate synthase.	0.911
purM	thiC	CLOTH_11660	CLOTH_16860	Phosphoribosylformylglycinamidine cyclo-ligase.	Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	0.868
tenI	OPJ55190.1	CLOTH_16850	CLOTH_16900	Regulatory protein TenI; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).	Sulfur carrier protein ThiS.	0.962
tenI	moeB	CLOTH_16850	CLOTH_16890	Regulatory protein TenI; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).	Molybdopterin-synthase adenylyltransferase.	0.931
tenI	thiC	CLOTH_16850	CLOTH_16860	Regulatory protein TenI; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).	Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	0.975

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