prs_2 protein (Clostridium thermoalcaliphilum)

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prs_2

Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)

Predicted Functional Partners:

glmU

0.968

purF

0.920

ywlF

0.911

pyrE

0.905

rbsK

0.904

guaA

0.895

deoB

0.891

dxs_2

0.875

tktA

0.874

nudF

0.873

Your Current Organism:

Clostridium thermoalcaliphilum

NCBI taxonomy Id: 29349
Other names: ATCC 51508, CIP 105528, DSM 7309, [. thermoalcaliphilum, [Clostridium] thermoalcaliphilum, strain JW/YL23-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
deoB	dxs_2	CLOTH_02480	CLOTH_15460	Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.	1-deoxy-D-xylulose-5-phosphate synthase.	0.867
deoB	guaA	CLOTH_02480	CLOTH_11700	Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.603
deoB	nudF	CLOTH_02480	CLOTH_02450	Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.	ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family.	0.934
deoB	prs_2	CLOTH_02480	CLOTH_17450	Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.	Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.	0.891
deoB	rbsK	CLOTH_02480	CLOTH_03100	Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.	Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.	0.857
deoB	tktA	CLOTH_02480	CLOTH_15470	Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.	Transketolase 1.	0.871
deoB	ywlF	CLOTH_02480	CLOTH_15750	Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.	Putative sugar phosphate isomerase YwlF.	0.891
dxs_2	deoB	CLOTH_15460	CLOTH_02480	1-deoxy-D-xylulose-5-phosphate synthase.	Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.	0.867
dxs_2	prs_2	CLOTH_15460	CLOTH_17450	1-deoxy-D-xylulose-5-phosphate synthase.	Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.	0.875
dxs_2	rbsK	CLOTH_15460	CLOTH_03100	1-deoxy-D-xylulose-5-phosphate synthase.	Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.	0.873
dxs_2	tktA	CLOTH_15460	CLOTH_15470	1-deoxy-D-xylulose-5-phosphate synthase.	Transketolase 1.	0.999
dxs_2	ywlF	CLOTH_15460	CLOTH_15750	1-deoxy-D-xylulose-5-phosphate synthase.	Putative sugar phosphate isomerase YwlF.	0.884
glmU	prs_2	CLOTH_17440	CLOTH_17450	Bifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.	0.968
guaA	deoB	CLOTH_11700	CLOTH_02480	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.	0.603
guaA	prs_2	CLOTH_11700	CLOTH_17450	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.	0.895
guaA	purF	CLOTH_11700	CLOTH_11670	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.	0.922
guaA	pyrE	CLOTH_11700	CLOTH_11850	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).	0.816
guaA	rbsK	CLOTH_11700	CLOTH_03100	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.	0.842
guaA	ywlF	CLOTH_11700	CLOTH_15750	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Putative sugar phosphate isomerase YwlF.	0.597
nudF	deoB	CLOTH_02450	CLOTH_02480	ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family.	Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.	0.934

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