Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
spoIIEStage II sporulation protein E. (789 aa)    
Predicted Functional Partners:
spoIIGA
Sporulation sigma-E factor-processing peptidase; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family.
  
  
 0.954
yabP
Spore protein YabP.
 
     0.881
OPJ54808.1
Stage II sporulation protein SpoIIR.
  
   
 0.875
sigE
RNA polymerase sigma-35 factor precursor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.859
OPJ55597.1
Stage II sporulation protein SpoIIP.
  
   
 0.855
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.850
spoIIID
Stage III sporulation protein D.
  
   
 0.831
OPJ56936.1
Hypothetical protein; Transcription termination factor Rho.
  
   
 0.816
OPJ56942.1
Hypothetical protein.
  
   
 0.788
spoVT
Stage V sporulation protein T.
 
   
 0.773
Your Current Organism:
Clostridium thermoalcaliphilum
NCBI taxonomy Id: 29349
Other names: ATCC 51508, CIP 105528, DSM 7309, [. thermoalcaliphilum, [Clostridium] thermoalcaliphilum, strain JW/YL23-2
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