pyrG protein (Clostridium thermoalcaliphilum)

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pyrG

CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (531 aa)

Predicted Functional Partners:

guaA

0.977

rpsB

0.906

rpoB

0.902

pnp

0.872

argS

0.833

rho

0.798

maf

0.785

carB

0.778

rplA

0.777

pyrH

0.776

Your Current Organism:

Clostridium thermoalcaliphilum

NCBI taxonomy Id: 29349
Other names: ATCC 51508, CIP 105528, DSM 7309, [. thermoalcaliphilum, [Clostridium] thermoalcaliphilum, strain JW/YL23-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
argS	guaA	CLOTH_16700	CLOTH_11700	arginine--tRNA ligase.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.978
argS	pnp	CLOTH_16700	CLOTH_04230	arginine--tRNA ligase.	Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.	0.614
argS	pyrG	CLOTH_16700	CLOTH_17630	arginine--tRNA ligase.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.833
argS	rho	CLOTH_16700	CLOTH_15840	arginine--tRNA ligase.	Hypothetical protein; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.	0.411
argS	rplA	CLOTH_16700	CLOTH_18700	arginine--tRNA ligase.	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	0.591
argS	rpoB	CLOTH_16700	CLOTH_18670	arginine--tRNA ligase.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.677
argS	rpsB	CLOTH_16700	CLOTH_04020	arginine--tRNA ligase.	30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.	0.508
carB	guaA	CLOTH_11410	CLOTH_11700	Carbamoyl-phosphate synthase large chain.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.907
carB	pyrG	CLOTH_11410	CLOTH_17630	Carbamoyl-phosphate synthase large chain.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.778
carB	pyrH	CLOTH_11410	CLOTH_04040	Carbamoyl-phosphate synthase large chain.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.406
carB	rpoB	CLOTH_11410	CLOTH_18670	Carbamoyl-phosphate synthase large chain.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.426
guaA	argS	CLOTH_11700	CLOTH_16700	GMP synthase; Catalyzes the synthesis of GMP from XMP.	arginine--tRNA ligase.	0.978
guaA	carB	CLOTH_11700	CLOTH_11410	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Carbamoyl-phosphate synthase large chain.	0.907
guaA	maf	CLOTH_11700	CLOTH_12840	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	0.425
guaA	pnp	CLOTH_11700	CLOTH_04230	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.	0.888
guaA	pyrG	CLOTH_11700	CLOTH_17630	GMP synthase; Catalyzes the synthesis of GMP from XMP.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.977
guaA	pyrH	CLOTH_11700	CLOTH_04040	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.844
guaA	rho	CLOTH_11700	CLOTH_15840	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Hypothetical protein; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.	0.497
guaA	rplA	CLOTH_11700	CLOTH_18700	GMP synthase; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	0.951
guaA	rpoB	CLOTH_11700	CLOTH_18670	GMP synthase; Catalyzes the synthesis of GMP from XMP.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.927

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