| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IO98_02580 | IO98_02585 | IO98_02580 | IO98_02585 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.594 |
| IO98_02585 | IO98_02580 | IO98_02585 | IO98_02580 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.594 |
| IO98_02585 | IO98_02590 | IO98_02585 | IO98_02590 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | dTDP-glucose 4,6-dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.819 |
| IO98_02585 | IO98_16635 | IO98_02585 | IO98_16635 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. | 0.579 |
| IO98_02585 | dxr | IO98_02585 | IO98_13335 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.964 |
| IO98_02585 | dxs | IO98_02585 | IO98_00730 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.688 |
| IO98_02585 | ispD | IO98_02585 | IO98_02865 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.850 |
| IO98_02585 | ispE | IO98_02585 | IO98_12645 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.964 |
| IO98_02585 | ispF | IO98_02585 | IO98_05740 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.998 |
| IO98_02585 | ispG | IO98_02585 | IO98_13345 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.896 |
| IO98_02585 | ispH | IO98_02585 | IO98_18855 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.785 |
| IO98_02590 | IO98_02585 | IO98_02590 | IO98_02585 | dTDP-glucose 4,6-dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.819 |
| IO98_16635 | IO98_02585 | IO98_16635 | IO98_02585 | Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.579 |
| IO98_16635 | dxs | IO98_16635 | IO98_00730 | Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.580 |
| IO98_16635 | ispD | IO98_16635 | IO98_02865 | Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.579 |
| dxr | IO98_02585 | IO98_13335 | IO98_02585 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.964 |
| dxr | dxs | IO98_13335 | IO98_00730 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.984 |
| dxr | ispD | IO98_13335 | IO98_02865 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.979 |
| dxr | ispE | IO98_13335 | IO98_12645 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.858 |
| dxr | ispF | IO98_13335 | IO98_05740 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.968 |