Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
IO98_08045DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)    
Predicted Functional Partners:
ku
DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.978
IO98_22140
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.972
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 0.955
IO98_02510
HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.914
IO98_17230
5'-3' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.895
IO98_08540
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.850
IO98_23580
Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.828
IO98_10735
Helicase SNF2; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.791
IO98_16485
Metallo-beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.739
IO98_11495
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.738
Your Current Organism:
Clostridium celerecrescens
NCBI taxonomy Id: 29354
Other names: ATCC 49205, CECT 954, Clostridium celericrescens, DSM 5628, [. celerecrescens, [Clostridium] celerecrescens, strain 18A
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