Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
IO98_08095Ribonucleoside-triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (690 aa)    
Predicted Functional Partners:
IO98_15580
Response regulator SirA; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 
 0.993
IO98_09675
Ribonucleoside-triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
0.958
IO98_10745
Ribonucleoside-triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
0.945
IO98_19700
Ribonucleoside-triphosphate reductase activating protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.938
IO98_09660
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
    
 0.906
IO98_10320
Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.903
ribBA
GTP cyclohydrolase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
   
 0.898
IO98_09400
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
  0.892
IO98_19450
GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
 0.891
dcd
Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
  
 
 0.891
Your Current Organism:
Clostridium celerecrescens
NCBI taxonomy Id: 29354
Other names: ATCC 49205, CECT 954, Clostridium celericrescens, DSM 5628, [. celerecrescens, [Clostridium] celerecrescens, strain 18A
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