acpP protein (Clostridium polysaccharolyticum)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

acpP

Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa)

Predicted Functional Partners:

SES92613.1

0.990

SET40022.1

0.987

SET42771.1

0.984

SET49269.1

0.982

SES92583.1

0.968

SES92591.1

0.959

SET05102.1

0.936

SES76685.1

0.913

SES78743.1

0.897

acpP-2

0.896

Your Current Organism:

Clostridium polysaccharolyticum

NCBI taxonomy Id: 29364
Other names: ATCC 33142, Fusobacterium polysaccharolyticum, [. polysaccharolyticum, [Clostridium] polysaccharolyticum, strain B

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SES76685.1	SES92583.1	SAMN04487772_1033	SAMN04487772_105115	Thioester reductase domain-containing protein.	Phosphopantetheine attachment site.	0.999
SES76685.1	SES92591.1	SAMN04487772_1033	SAMN04487772_105116	Thioester reductase domain-containing protein.	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II.	0.997
SES76685.1	SES92613.1	SAMN04487772_1033	SAMN04487772_105117	Thioester reductase domain-containing protein.	Amino acid adenylation domain-containing protein.	0.999
SES76685.1	SET05102.1	SAMN04487772_1033	SAMN04487772_10792	Thioester reductase domain-containing protein.	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	0.999
SES76685.1	SET40022.1	SAMN04487772_1033	SAMN04487772_11852	Thioester reductase domain-containing protein.	Phosphopantetheine attachment site.	0.999
SES76685.1	SET42771.1	SAMN04487772_1033	SAMN04487772_1208	Thioester reductase domain-containing protein.	Pyochelin synthetase.	0.999
SES76685.1	SET49269.1	SAMN04487772_1033	SAMN04487772_12515	Thioester reductase domain-containing protein.	Acyl transferase domain-containing protein.	0.999
SES76685.1	acpP	SAMN04487772_1033	SAMN04487772_10582	Thioester reductase domain-containing protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.913
SES76685.1	acpP-2	SAMN04487772_1033	SAMN04487772_1138	Thioester reductase domain-containing protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.901
SES78743.1	SES92591.1	SAMN04487772_103104	SAMN04487772_105116	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II.	0.992
SES78743.1	SES92613.1	SAMN04487772_103104	SAMN04487772_105117	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	Amino acid adenylation domain-containing protein.	0.996
SES78743.1	SET40022.1	SAMN04487772_103104	SAMN04487772_11852	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	Phosphopantetheine attachment site.	0.997
SES78743.1	SET42771.1	SAMN04487772_103104	SAMN04487772_1208	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	Pyochelin synthetase.	0.920
SES78743.1	SET49269.1	SAMN04487772_103104	SAMN04487772_12515	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	Acyl transferase domain-containing protein.	0.996
SES78743.1	acpP	SAMN04487772_103104	SAMN04487772_10582	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.897
SES78743.1	acpP-2	SAMN04487772_103104	SAMN04487772_1138	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.897
SES92583.1	SES76685.1	SAMN04487772_105115	SAMN04487772_1033	Phosphopantetheine attachment site.	Thioester reductase domain-containing protein.	0.999
SES92583.1	SES92591.1	SAMN04487772_105115	SAMN04487772_105116	Phosphopantetheine attachment site.	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II.	0.999
SES92583.1	SES92613.1	SAMN04487772_105115	SAMN04487772_105117	Phosphopantetheine attachment site.	Amino acid adenylation domain-containing protein.	0.999
SES92583.1	SET05102.1	SAMN04487772_105115	SAMN04487772_10792	Phosphopantetheine attachment site.	Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family.	0.999

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Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.875

expected number of edges:

11

PPI enrichment p-value:

1.23e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046417

Chorismate metabolic process

7 of 10

2.51

6.15

3.95e-13

GO:0009073

Aromatic amino acid family biosynthetic process

6 of 15

2.27

4.51

3.75e-10

GO:0009423

Chorismate biosynthetic process

5 of 8

2.46

4.25

4.57e-09

GO:0016053

Organic acid biosynthetic process

8 of 158

1.37

2.06

2.70e-08

GO:0008652

Cellular amino acid biosynthetic process

6 of 99

1.45

1.91

2.07e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016838

Carbon-oxygen lyase activity, acting on phosphates

3 of 5

2.45

1.93

0.00025

GO:0003856

3-dehydroquinate synthase activity

2 of 2

2.67

1.16

0.0077

GO:0004106

Chorismate mutase activity

2 of 3

2.49

1.13

0.0085

GO:0003824

Catalytic activity

11 of 2353

0.34

0.26

0.0241

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

9 of 1151

0.56

0.41

0.0065

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:831

Aromatic amino acid family metabolic process, and Anthranilate synthase component I-like

7 of 17

2.28

5.23

6.87e-12

CL:833

Prephenate dehydratase, and Enolpyruvate transferase domain

4 of 5

2.57

3.38

4.03e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

8 of 25

2.17

5.85

2.40e-14

map01230

Biosynthesis of amino acids

8 of 140

1.42

2.31

3.82e-09

map01110

Biosynthesis of secondary metabolites

8 of 486

0.88

0.85

3.72e-05

map01100

Metabolic pathways

11 of 1481

0.54

0.47

3.85e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

6 of 388

0.86

0.59

0.0085

GOCC:0005737

Cytoplasm

9 of 957

0.64

0.49

0.0029

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

4 of 12

2.19

2.69

4.26e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01761

3-dehydroquinate synthase

2 of 2

2.67

0.99

0.0159

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036979

Chorismate mutase domain superfamily

2 of 2

2.67

0.78

0.0384

IPR036263

Chorismate mutase type II superfamily

2 of 2

2.67

0.78

0.0384

IPR030960

3-dehydroquinate synthase domain

2 of 2

2.67

0.78

0.0384

IPR002701

Chorismate mutase II, prokaryotic-type

2 of 2

2.67

0.78

0.0384

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00830

Chorismate mutase type II

2 of 2

2.67

1.37

0.0032

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