Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nfo_1Putative endonuclease 4. (64 aa)    
Predicted Functional Partners:
exoA
Exodeoxyribonuclease.
    
 0.877
pdg
Ultraviolet N-glycosylase/AP lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.803
ung
uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
   
 
 0.792
alkA_2
DNA-3-methyladenine glycosylase.
  
 
 
 0.655
alkA_1
DNA-3-methyladenine glycosylase.
    
 
 0.611
alkA_3
DNA-3-methyladenine glycosylase.
    
 
 0.611
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
 
 0.590
polA_2
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.574
OOM82302.1
Ca(2+)/H(+) antiporter; Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons.
   
    0.486
sodA1
Superoxide dismutase 1; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.482
Your Current Organism:
Clostridium puniceum
NCBI taxonomy Id: 29367
Other names: ATCC 43978, C. puniceum, DSM 2619, ICMP 12529, NCIB 11596, NCIB:11596, NCIMB 11596, strain BL 70/20
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