mgsR protein (Clostridium puniceum) - STRING interaction network

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mgsR

Regulatory protein MgsR; Belongs to the ArsC family. (120 aa)

Predicted Functional Partners:

rpoA

0.723

OOM74307.1

0.645

OOM74215.1

0.635

folD

0.572

thyA1

0.515

glnA_1

0.502

glyA

0.489

folA

0.480

tpx

0.474

srrB

0.469

Your Current Organism:

Clostridium puniceum

NCBI taxonomy Id: 29367
Other names: ATCC 43978, C. puniceum, DSM 2619, ICMP 12529, NCIB 11596, NCIB:11596, NCIMB 11596, strain BL 70/20

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OOM74215.1	mgsR	CLPUN_40970	CLPUN_20580	DSBA-like thioredoxin domain protein.	Regulatory protein MgsR; Belongs to the ArsC family.	0.635
OOM74307.1	mgsR	CLPUN_40120	CLPUN_20580	DSBA-like thioredoxin domain protein.	Regulatory protein MgsR; Belongs to the ArsC family.	0.645
folA	folD	CLPUN_20590	CLPUN_11500	Dihydrofolate reductase.	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.546
folA	glyA	CLPUN_20590	CLPUN_26920	Dihydrofolate reductase.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.629
folA	mgsR	CLPUN_20590	CLPUN_20580	Dihydrofolate reductase.	Regulatory protein MgsR; Belongs to the ArsC family.	0.480
folA	thyA1	CLPUN_20590	CLPUN_07650	Dihydrofolate reductase.	Thymidylate synthase 1; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.963
folD	folA	CLPUN_11500	CLPUN_20590	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Dihydrofolate reductase.	0.546
folD	glyA	CLPUN_11500	CLPUN_26920	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.988
folD	mgsR	CLPUN_11500	CLPUN_20580	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Regulatory protein MgsR; Belongs to the ArsC family.	0.572
folD	thyA1	CLPUN_11500	CLPUN_07650	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Thymidylate synthase 1; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.917
glnA_1	glyA	CLPUN_45930	CLPUN_26920	Glutamine synthetase.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.757
glnA_1	mgsR	CLPUN_45930	CLPUN_20580	Glutamine synthetase.	Regulatory protein MgsR; Belongs to the ArsC family.	0.502
glyA	folA	CLPUN_26920	CLPUN_20590	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Dihydrofolate reductase.	0.629
glyA	folD	CLPUN_26920	CLPUN_11500	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.988
glyA	glnA_1	CLPUN_26920	CLPUN_45930	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Glutamine synthetase.	0.757
glyA	mgsR	CLPUN_26920	CLPUN_20580	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Regulatory protein MgsR; Belongs to the ArsC family.	0.489
glyA	thyA1	CLPUN_26920	CLPUN_07650	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Thymidylate synthase 1; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.884
mgsR	OOM74215.1	CLPUN_20580	CLPUN_40970	Regulatory protein MgsR; Belongs to the ArsC family.	DSBA-like thioredoxin domain protein.	0.635
mgsR	OOM74307.1	CLPUN_20580	CLPUN_40120	Regulatory protein MgsR; Belongs to the ArsC family.	DSBA-like thioredoxin domain protein.	0.645
mgsR	folA	CLPUN_20580	CLPUN_20590	Regulatory protein MgsR; Belongs to the ArsC family.	Dihydrofolate reductase.	0.480