| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| carA | preA | CLPUN_37480 | CLPUN_24620 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | 0.973 |
| carA | pyrB | CLPUN_37480 | CLPUN_40270 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carA | pyrC | CLPUN_37480 | CLPUN_40250 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.998 |
| carA | pyrD | CLPUN_37480 | CLPUN_40220 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Dihydroorotate dehydrogenase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. | 0.974 |
| carA | pyrE | CLPUN_37480 | CLPUN_40210 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.957 |
| carA | pyrF | CLPUN_37480 | CLPUN_40240 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.924 |
| carA | pyrI | CLPUN_37480 | CLPUN_40260 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Aspartate carbamoyltransferase regulatory chain. | 0.966 |
| carA | pyrK_4 | CLPUN_37480 | CLPUN_40230 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Dihydroorotate dehydrogenase B, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.944 |
| carA | pyrR | CLPUN_37480 | CLPUN_11830 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Bifunctional protein PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.885 |
| carA | upp | CLPUN_37480 | CLPUN_50540 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.650 |
| preA | carA | CLPUN_24620 | CLPUN_37480 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | 0.973 |
| preA | pyrB | CLPUN_24620 | CLPUN_40270 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.947 |
| preA | pyrC | CLPUN_24620 | CLPUN_40250 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.990 |
| preA | pyrD | CLPUN_24620 | CLPUN_40220 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Dihydroorotate dehydrogenase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. | 0.878 |
| preA | pyrE | CLPUN_24620 | CLPUN_40210 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.973 |
| preA | pyrF | CLPUN_24620 | CLPUN_40240 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.948 |
| preA | pyrI | CLPUN_24620 | CLPUN_40260 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Aspartate carbamoyltransferase regulatory chain. | 0.622 |
| preA | pyrK_4 | CLPUN_24620 | CLPUN_40230 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Dihydroorotate dehydrogenase B, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.991 |
| preA | pyrR | CLPUN_24620 | CLPUN_11830 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Bifunctional protein PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.945 |
| preA | upp | CLPUN_24620 | CLPUN_50540 | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.872 |
