| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| dmdB | ilvB_4 | CLPUN_01560 | CLPUN_46340 | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 0.868 |
| dmdB | ilvC_1 | CLPUN_01560 | CLPUN_01530 | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.967 |
| dmdB | ilvD_1 | CLPUN_01560 | CLPUN_32970 | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.848 |
| dmdB | ilvD_2 | CLPUN_01560 | CLPUN_40090 | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.760 |
| dmdB | ilvH | CLPUN_01560 | CLPUN_01590 | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | Acetolactate synthase small subunit. | 0.985 |
| dmdB | ilvN | CLPUN_01560 | CLPUN_41670 | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | Acetolactate synthase isozyme 1 small subunit. | 0.912 |
| dmdB | leuB | CLPUN_01560 | CLPUN_01550 | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.999 |
| dmdB | nifJ_1 | CLPUN_01560 | CLPUN_20720 | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | Pyruvate-flavodoxin oxidoreductase. | 0.814 |
| dmdB | nifJ_2 | CLPUN_01560 | CLPUN_42950 | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | Pyruvate-flavodoxin oxidoreductase. | 0.814 |
| dmdB | tdcB | CLPUN_01560 | CLPUN_12180 | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | L-threonine dehydratase catabolic TdcB. | 0.525 |
| ilvB_4 | dmdB | CLPUN_46340 | CLPUN_01560 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.868 |
| ilvB_4 | ilvC_1 | CLPUN_46340 | CLPUN_01530 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.978 |
| ilvB_4 | ilvD_1 | CLPUN_46340 | CLPUN_32970 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.902 |
| ilvB_4 | ilvD_2 | CLPUN_46340 | CLPUN_40090 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.869 |
| ilvB_4 | ilvH | CLPUN_46340 | CLPUN_01590 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase small subunit. | 0.978 |
| ilvB_4 | ilvN | CLPUN_46340 | CLPUN_41670 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase isozyme 1 small subunit. | 0.949 |
| ilvB_4 | leuB | CLPUN_46340 | CLPUN_01550 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.925 |
| ilvB_4 | nifJ_1 | CLPUN_46340 | CLPUN_20720 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Pyruvate-flavodoxin oxidoreductase. | 0.925 |
| ilvB_4 | nifJ_2 | CLPUN_46340 | CLPUN_42950 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Pyruvate-flavodoxin oxidoreductase. | 0.925 |
| ilvB_4 | tdcB | CLPUN_46340 | CLPUN_12180 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | L-threonine dehydratase catabolic TdcB. | 0.905 |
