topA protein (Clostridium puniceum) - STRING interaction network

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topA

DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (697 aa)

Predicted Functional Partners:

rpoC

0.954

rpoA

0.945

nifJ_1

0.932

nifJ_2

0.932

leuS

0.929

rpoB

0.915

rnd

0.887

recQ_1

0.887

recQ_2

0.887

OOM72295.1

0.873

Your Current Organism:

Clostridium puniceum

NCBI taxonomy Id: 29367
Other names: ATCC 43978, C. puniceum, DSM 2619, ICMP 12529, NCIB 11596, NCIB:11596, NCIMB 11596, strain BL 70/20

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OOM72295.1	topA	CLPUN_47630	CLPUN_47640	Hypothetical protein.	DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.873
leuS	nifJ_1	CLPUN_48330	CLPUN_20720	leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Pyruvate-flavodoxin oxidoreductase.	0.720
leuS	nifJ_2	CLPUN_48330	CLPUN_42950	leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Pyruvate-flavodoxin oxidoreductase.	0.720
leuS	rpoA	CLPUN_48330	CLPUN_09250	leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.714
leuS	rpoB	CLPUN_48330	CLPUN_08890	leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.826
leuS	rpoC	CLPUN_48330	CLPUN_08900	leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.614
leuS	topA	CLPUN_48330	CLPUN_47640	leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.929
nifJ_1	leuS	CLPUN_20720	CLPUN_48330	Pyruvate-flavodoxin oxidoreductase.	leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.720
nifJ_1	nifJ_2	CLPUN_20720	CLPUN_42950	Pyruvate-flavodoxin oxidoreductase.	Pyruvate-flavodoxin oxidoreductase.	0.999
nifJ_1	rpoA	CLPUN_20720	CLPUN_09250	Pyruvate-flavodoxin oxidoreductase.	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.568
nifJ_1	rpoB	CLPUN_20720	CLPUN_08890	Pyruvate-flavodoxin oxidoreductase.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.581
nifJ_1	topA	CLPUN_20720	CLPUN_47640	Pyruvate-flavodoxin oxidoreductase.	DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.932
nifJ_2	leuS	CLPUN_42950	CLPUN_48330	Pyruvate-flavodoxin oxidoreductase.	leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.720
nifJ_2	nifJ_1	CLPUN_42950	CLPUN_20720	Pyruvate-flavodoxin oxidoreductase.	Pyruvate-flavodoxin oxidoreductase.	0.999
nifJ_2	rpoA	CLPUN_42950	CLPUN_09250	Pyruvate-flavodoxin oxidoreductase.	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.568
nifJ_2	rpoB	CLPUN_42950	CLPUN_08890	Pyruvate-flavodoxin oxidoreductase.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.581
nifJ_2	topA	CLPUN_42950	CLPUN_47640	Pyruvate-flavodoxin oxidoreductase.	DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.932
recQ_1	recQ_2	CLPUN_25320	CLPUN_43040	ATP-dependent DNA helicase RecQ.	ATP-dependent DNA helicase RecQ.	0.560
recQ_1	rpoA	CLPUN_25320	CLPUN_09250	ATP-dependent DNA helicase RecQ.	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.506
recQ_1	rpoB	CLPUN_25320	CLPUN_08890	ATP-dependent DNA helicase RecQ.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.624

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