node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Amet_0002 | Amet_0003 | Amet_0002 | Amet_0003 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: RNA-binding S4 domain protein; KEGG: cth:Cthe_2373 RNA-binding S4. | 0.847 |
Amet_0002 | Amet_0005 | Amet_0002 | Amet_0005 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | KEGG: cth:Cthe_2375 hypothetical protein. | 0.599 |
Amet_0002 | gyrA | Amet_0002 | Amet_0007 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.782 |
Amet_0002 | gyrB | Amet_0002 | Amet_0006 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.930 |
Amet_0002 | recF | Amet_0002 | Amet_0004 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.960 |
Amet_0003 | Amet_0002 | Amet_0003 | Amet_0002 | PFAM: RNA-binding S4 domain protein; KEGG: cth:Cthe_2373 RNA-binding S4. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.847 |
Amet_0003 | Amet_0005 | Amet_0003 | Amet_0005 | PFAM: RNA-binding S4 domain protein; KEGG: cth:Cthe_2373 RNA-binding S4. | KEGG: cth:Cthe_2375 hypothetical protein. | 0.621 |
Amet_0003 | gyrA | Amet_0003 | Amet_0007 | PFAM: RNA-binding S4 domain protein; KEGG: cth:Cthe_2373 RNA-binding S4. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.566 |
Amet_0003 | gyrB | Amet_0003 | Amet_0006 | PFAM: RNA-binding S4 domain protein; KEGG: cth:Cthe_2373 RNA-binding S4. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.593 |
Amet_0003 | recF | Amet_0003 | Amet_0004 | PFAM: RNA-binding S4 domain protein; KEGG: cth:Cthe_2373 RNA-binding S4. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.892 |
Amet_0005 | Amet_0002 | Amet_0005 | Amet_0002 | KEGG: cth:Cthe_2375 hypothetical protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.599 |
Amet_0005 | Amet_0003 | Amet_0005 | Amet_0003 | KEGG: cth:Cthe_2375 hypothetical protein. | PFAM: RNA-binding S4 domain protein; KEGG: cth:Cthe_2373 RNA-binding S4. | 0.621 |
Amet_0005 | Amet_0393 | Amet_0005 | Amet_0393 | KEGG: cth:Cthe_2375 hypothetical protein. | Transcriptional regulator/antitoxin, MazE; PFAM: SpoVT/AbrB domain protein; KEGG: swo:Swol_0047 transcription regulator AbrB. | 0.514 |
Amet_0005 | Amet_1368 | Amet_0005 | Amet_1368 | KEGG: cth:Cthe_2375 hypothetical protein. | TIGRFAM: Spore germination YpeB; PFAM: Propeptide, PepSY amd peptidase M4; KEGG: cth:Cthe_2416 propeptide, PepSY amd peptidase M4. | 0.499 |
Amet_0005 | Amet_1931 | Amet_0005 | Amet_1931 | KEGG: cth:Cthe_2375 hypothetical protein. | Transcriptional regulator/antitoxin, MazE; PFAM: SpoVT/AbrB domain protein; KEGG: swo:Swol_0047 transcription regulator AbrB. | 0.513 |
Amet_0005 | Amet_4389 | Amet_0005 | Amet_4389 | KEGG: cth:Cthe_2375 hypothetical protein. | Transcriptional regulator/antitoxin, MazE; PFAM: SpoVT/AbrB domain protein; KEGG: swo:Swol_0047 transcription regulator AbrB. | 0.514 |
Amet_0005 | Amet_4606 | Amet_0005 | Amet_4606 | KEGG: cth:Cthe_2375 hypothetical protein. | KEGG: tte:TTE0861 hypothetical protein. | 0.524 |
Amet_0005 | gyrA | Amet_0005 | Amet_0007 | KEGG: cth:Cthe_2375 hypothetical protein. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.720 |
Amet_0005 | gyrB | Amet_0005 | Amet_0006 | KEGG: cth:Cthe_2375 hypothetical protein. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.753 |
Amet_0005 | recF | Amet_0005 | Amet_0004 | KEGG: cth:Cthe_2375 hypothetical protein. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.777 |