STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Amet_1078TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: tma:TM0141 anthranilate synthase component II / anthranilate phosphoribosyltransferase. (187 aa)    
Predicted Functional Partners:
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 0.999
Amet_2158
TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein; KEGG: cno:NT01CX_0379 anthranilate synthase component I.
 0.999
trpC
PFAM: Indole-3-glycerol phosphate synthase; KEGG: cth:Cthe_0872 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family.
  
 0.998
trpF
PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: tte:TTE1579 phosphoribosylanthranilate isomerase; Belongs to the TrpF family.
  
 0.998
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
 0.984
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.974
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.949
Amet_0565
KEGG: cth:Cthe_1377 amino acid-binding ACT; Belongs to the UPF0735 family.
     
  0.900
Amet_2157
TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: cno:NT01CX_0380 anthranilate synthase component II.
  
  
 
0.808
Your Current Organism:
Alkaliphilus metalliredigens
NCBI taxonomy Id: 293826
Other names: A. metalliredigens QYMF, Alkaliphilus metalliredigens QYMF, Alkaliphilus metalliredigens str. QYMF, Alkaliphilus metalliredigens strain QYMF
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.