node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Amet_1319 | Amet_4657 | Amet_1319 | Amet_4657 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: cac:CAC0972 isocitrate dehydrogenase. | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: tte:TTE0445 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit. | 0.447 |
Amet_1319 | ilvC | Amet_1319 | Amet_3402 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: cac:CAC0972 isocitrate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.865 |
Amet_1319 | leuA | Amet_1319 | Amet_3458 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: cac:CAC0972 isocitrate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.707 |
Amet_1319 | leuC | Amet_1319 | Amet_2963 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: cac:CAC0972 isocitrate dehydrogenase. | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.900 |
Amet_1319 | leuC-2 | Amet_1319 | Amet_3457 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: cac:CAC0972 isocitrate dehydrogenase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.857 |
Amet_1319 | leuD | Amet_1319 | Amet_2962 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: cac:CAC0972 isocitrate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.824 |
Amet_1319 | leuD-2 | Amet_1319 | Amet_3456 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: cac:CAC0972 isocitrate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.867 |
Amet_4068 | Amet_4657 | Amet_4068 | Amet_4657 | TIGRFAM: pyruvate kinase; PFAM: PEP-utilising protein, mobile region; Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; KEGG: tte:TTE1815 pyruvate kinase; Belongs to the pyruvate kinase family. | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: tte:TTE0445 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit. | 0.984 |
Amet_4068 | leuA | Amet_4068 | Amet_3458 | TIGRFAM: pyruvate kinase; PFAM: PEP-utilising protein, mobile region; Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; KEGG: tte:TTE1815 pyruvate kinase; Belongs to the pyruvate kinase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.823 |
Amet_4068 | leuC | Amet_4068 | Amet_2963 | TIGRFAM: pyruvate kinase; PFAM: PEP-utilising protein, mobile region; Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; KEGG: tte:TTE1815 pyruvate kinase; Belongs to the pyruvate kinase family. | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.822 |
Amet_4068 | leuC-2 | Amet_4068 | Amet_3457 | TIGRFAM: pyruvate kinase; PFAM: PEP-utilising protein, mobile region; Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; KEGG: tte:TTE1815 pyruvate kinase; Belongs to the pyruvate kinase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.822 |
Amet_4068 | leuD | Amet_4068 | Amet_2962 | TIGRFAM: pyruvate kinase; PFAM: PEP-utilising protein, mobile region; Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; KEGG: tte:TTE1815 pyruvate kinase; Belongs to the pyruvate kinase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.841 |
Amet_4068 | leuD-2 | Amet_4068 | Amet_3456 | TIGRFAM: pyruvate kinase; PFAM: PEP-utilising protein, mobile region; Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; KEGG: tte:TTE1815 pyruvate kinase; Belongs to the pyruvate kinase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.841 |
Amet_4274 | Amet_4657 | Amet_4274 | Amet_4657 | TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: msu:MS1105 isocitrate/isopropylmalate dehydrogenase. | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: tte:TTE0445 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit. | 0.942 |
Amet_4274 | ilvC | Amet_4274 | Amet_3402 | TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: msu:MS1105 isocitrate/isopropylmalate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.831 |
Amet_4274 | leuA | Amet_4274 | Amet_3458 | TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: msu:MS1105 isocitrate/isopropylmalate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.653 |
Amet_4274 | leuC | Amet_4274 | Amet_2963 | TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: msu:MS1105 isocitrate/isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.955 |
Amet_4274 | leuC-2 | Amet_4274 | Amet_3457 | TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: msu:MS1105 isocitrate/isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.948 |
Amet_4274 | leuD | Amet_4274 | Amet_2962 | TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: msu:MS1105 isocitrate/isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.828 |
Amet_4274 | leuD-2 | Amet_4274 | Amet_3456 | TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: msu:MS1105 isocitrate/isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.827 |