STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Amet_4220PFAM: DEAD_2 domain protein; SMART: DEXDc2; helicase c2; KEGG: cth:Cthe_0289 DEAD_2. (781 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 0.893
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
 0.883
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 0.876
Amet_1785
PFAM: helicase domain protein; DNA primase, small subunit; type III restriction protein, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like; KEGG: dsy:DSY4376 hypothetical protein.
   
 0.863
Amet_2840
Hypothetical protein.
   
 0.863
Amet_2144
PFAM: sigma-70 region 4 domain protein; RNA polymerase, alpha subunit domain protein; KEGG: ppe:PEPE_0533 hypothetical protein.
 
 0.820
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
  
 0.767
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.765
Amet_4219
Putative transcriptional regulator, MerR family; PFAM: regulatory protein, MerR; Methyltransferase type 11; KEGG: btl:BALH_2398 possible transcriptional regulator, MerR family.
       0.697
Amet_0669
D-proline reductase (dithiol).
   
 0.651
Your Current Organism:
Alkaliphilus metalliredigens
NCBI taxonomy Id: 293826
Other names: A. metalliredigens QYMF, Alkaliphilus metalliredigens QYMF, Alkaliphilus metalliredigens str. QYMF, Alkaliphilus metalliredigens strain QYMF
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