| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMG18846.1 | AMG19784.1 | AL528_00710 | AL528_05965 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0741 family. | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | 0.447 |
| AMG18851.1 | AMG19784.1 | AL528_00740 | AL528_05965 | Heme-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | 0.927 |
| AMG18851.1 | ctaB | AL528_00740 | AL528_11305 | Heme-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. | 0.928 |
| AMG18851.1 | hemH | AL528_00740 | AL528_07410 | Heme-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.981 |
| AMG19464.1 | AMG19784.1 | AL528_04265 | AL528_05965 | Derived by automated computational analysis using gene prediction method: Protein Homology. | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | 0.517 |
| AMG19617.1 | AMG19784.1 | AL528_05110 | AL528_05965 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | 0.528 |
| AMG19784.1 | AMG18846.1 | AL528_05965 | AL528_00710 | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0741 family. | 0.447 |
| AMG19784.1 | AMG18851.1 | AL528_05965 | AL528_00740 | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | Heme-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.927 |
| AMG19784.1 | AMG19464.1 | AL528_05965 | AL528_04265 | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.517 |
| AMG19784.1 | AMG19617.1 | AL528_05965 | AL528_05110 | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.528 |
| AMG19784.1 | AMG19785.1 | AL528_05965 | AL528_05970 | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.523 |
| AMG19784.1 | AMG20826.1 | AL528_05965 | AL528_11635 | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | MarR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.456 |
| AMG19784.1 | AMG20915.1 | AL528_05965 | AL528_12105 | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.561 |
| AMG19784.1 | ctaB | AL528_05965 | AL528_11305 | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | Hypothetical protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. | 0.912 |
| AMG19784.1 | fecD | AL528_05965 | AL528_05955 | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | Iron-dicitrate transporter subunit FecD; Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter; Derived by automated computational an [...] | 0.435 |
| AMG19784.1 | hemH | AL528_05965 | AL528_07410 | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.903 |
| AMG19785.1 | AMG19784.1 | AL528_05970 | AL528_05965 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | 0.523 |
| AMG20826.1 | AMG19784.1 | AL528_11635 | AL528_05965 | MarR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | 0.456 |
| AMG20915.1 | AMG19784.1 | AL528_12105 | AL528_05965 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Heme-degrading monooxygenase IsdG; Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo- beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. | 0.561 |
| ctaB | AMG18851.1 | AL528_11305 | AL528_00740 | Hypothetical protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. | Heme-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.928 |
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