| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| acrB | macA_1 | SRM1_04429 | SRM1_00284 | Multidrug efflux pump subunit AcrB; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Macrolide export protein MacA. | 0.717 |
| acrB | mdtE | SRM1_04429 | SRM1_00283 | Multidrug efflux pump subunit AcrB; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Multidrug resistance protein MdtE precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.776 |
| bepE | macA_1 | SRM1_02793 | SRM1_00284 | Efflux pump membrane transporter BepE. | Macrolide export protein MacA. | 0.753 |
| bepE | macB | SRM1_02793 | SRM1_01945 | Efflux pump membrane transporter BepE. | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.460 |
| bepE | mdtE | SRM1_02793 | SRM1_00283 | Efflux pump membrane transporter BepE. | Multidrug resistance protein MdtE precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.808 |
| cnrA | macA_1 | SRM1_04512 | SRM1_00284 | Nickel and cobalt resistance protein CnrA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Macrolide export protein MacA. | 0.932 |
| cnrA | mdtE | SRM1_04512 | SRM1_00283 | Nickel and cobalt resistance protein CnrA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Multidrug resistance protein MdtE precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.949 |
| czcA_1 | macA_1 | SRM1_00285 | SRM1_00284 | Cobalt-zinc-cadmium resistance protein CzcA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Macrolide export protein MacA. | 0.984 |
| czcA_1 | mdtE | SRM1_00285 | SRM1_00283 | Cobalt-zinc-cadmium resistance protein CzcA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Multidrug resistance protein MdtE precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.988 |
| czcA_3 | macA_1 | SRM1_05859 | SRM1_00284 | Cobalt-zinc-cadmium resistance protein CzcA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Macrolide export protein MacA. | 0.601 |
| czcA_3 | mdtE | SRM1_05859 | SRM1_00283 | Cobalt-zinc-cadmium resistance protein CzcA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Multidrug resistance protein MdtE precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.617 |
| macA_1 | acrB | SRM1_00284 | SRM1_04429 | Macrolide export protein MacA. | Multidrug efflux pump subunit AcrB; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.717 |
| macA_1 | bepE | SRM1_00284 | SRM1_02793 | Macrolide export protein MacA. | Efflux pump membrane transporter BepE. | 0.753 |
| macA_1 | cnrA | SRM1_00284 | SRM1_04512 | Macrolide export protein MacA. | Nickel and cobalt resistance protein CnrA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.932 |
| macA_1 | czcA_1 | SRM1_00284 | SRM1_00285 | Macrolide export protein MacA. | Cobalt-zinc-cadmium resistance protein CzcA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.984 |
| macA_1 | czcA_3 | SRM1_00284 | SRM1_05859 | Macrolide export protein MacA. | Cobalt-zinc-cadmium resistance protein CzcA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.601 |
| macA_1 | macB | SRM1_00284 | SRM1_01945 | Macrolide export protein MacA. | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.944 |
| macA_1 | mdtC | SRM1_00284 | SRM1_02437 | Macrolide export protein MacA. | Multidrug resistance protein MdtC; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.618 |
| macA_1 | mdtE | SRM1_00284 | SRM1_00283 | Macrolide export protein MacA. | Multidrug resistance protein MdtE precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.848 |
| macA_1 | mexB | SRM1_00284 | SRM1_02837 | Macrolide export protein MacA. | Multidrug resistance protein MexB. | 0.753 |