tolC_1 protein (Pseudomonas fluorescens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

tolC_1

Outer membrane protein TolC precursor. (477 aa)

Predicted Functional Partners:

macB

0.784

emrA

0.672

emrK_1

0.666

mdtN_2

0.655

cusB

0.653

prsE_1

0.649

aprE

0.649

prsE_2

0.643

aaeA_1

0.614

mdtA_3

0.613

Your Current Organism:

Pseudomonas fluorescens

NCBI taxonomy Id: 294
Other names: ATCC 13525, Bacillus fluorescens, Bacillus fluorescens liquefaciens, Bacterium fluorescen, CCEB 546, CFBP 2102, CIP 69.13, DSM 50090, IAM 12022, IFO 14160, JCM 5963, Liquidomonas fluorescens, NBRC 14160, NCCB 76040, NCIB 9046, NCIB:9046, NCIMB 9046, NCTC 10038, NRRL B-14678, P. fluorescens, Pseudomonas sp. AU2390, Pseudomonas sp. BZ64, Pseudomonas sp. FY32, Pseudomonas sp. HSA2/2016, Pseudomonas sp. HSA3/2016, Pseudomonas sp. ISSDS-433, Pseudomonas sp. JCM 17186, Pseudomonas sp. JCM 2779, Pseudomonas sp. KH-20150KS3, Pseudomonas sp. LBUM223, Pseudomonas sp. LBUM636, Pseudomonas sp. SM2/2016, RH 818, VKM B-894, bacterium P1-1, strain M. Rhodes 28/5

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
aaeA_1	macB	SRM1_00213	SRM1_01945	P-hydroxybenzoic acid efflux pump subunit AaeA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.767
aaeA_1	tolC_1	SRM1_00213	SRM1_00543	P-hydroxybenzoic acid efflux pump subunit AaeA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Outer membrane protein TolC precursor.	0.614
aprE	macB	SRM1_02761	SRM1_01945	Type I secretion system membrane fusion protein.	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.767
aprE	tolC_1	SRM1_02761	SRM1_00543	Type I secretion system membrane fusion protein.	Outer membrane protein TolC precursor.	0.649
cusB	macB	SRM1_00007	SRM1_01945	Cation efflux system protein CusB precursor.	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.926
cusB	mdtA_3	SRM1_00007	SRM1_04513	Cation efflux system protein CusB precursor.	Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.551
cusB	tolC_1	SRM1_00007	SRM1_00543	Cation efflux system protein CusB precursor.	Outer membrane protein TolC precursor.	0.653
emrA	macB	SRM1_03488	SRM1_01945	Multidrug export protein EmrA.	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.798
emrA	tolC_1	SRM1_03488	SRM1_00543	Multidrug export protein EmrA.	Outer membrane protein TolC precursor.	0.672
emrK_1	macB	SRM1_00203	SRM1_01945	Putative multidrug resistance protein EmrK.	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.767
emrK_1	tolC_1	SRM1_00203	SRM1_00543	Putative multidrug resistance protein EmrK.	Outer membrane protein TolC precursor.	0.666
macB	aaeA_1	SRM1_01945	SRM1_00213	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	P-hydroxybenzoic acid efflux pump subunit AaeA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.767
macB	aprE	SRM1_01945	SRM1_02761	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Type I secretion system membrane fusion protein.	0.767
macB	cusB	SRM1_01945	SRM1_00007	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Cation efflux system protein CusB precursor.	0.926
macB	emrA	SRM1_01945	SRM1_03488	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Multidrug export protein EmrA.	0.798
macB	emrK_1	SRM1_01945	SRM1_00203	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Putative multidrug resistance protein EmrK.	0.767
macB	mdtA_3	SRM1_01945	SRM1_04513	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.912
macB	mdtN_2	SRM1_01945	SRM1_05586	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Multidrug resistance protein MdtN.	0.800
macB	prsE_1	SRM1_01945	SRM1_00200	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Type I secretion system membrane fusion protein PrsE.	0.767
macB	prsE_2	SRM1_01945	SRM1_01446	Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Type I secretion system membrane fusion protein PrsE.	0.767

page 1 of 2

Server load: low (28%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Textmining

Coexpression

Databases

Fusion

© STRING Consortium 2025

Credits

Access

Info

About