| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aceA | fumA | SRM1_03444 | SRM1_04395 | Isocitrate lyase. | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.821 |
| aceA | phnW_1 | SRM1_03444 | SRM1_02571 | Isocitrate lyase. | 2-aminoethylphosphonate--pyruvate transaminase. | 0.703 |
| dgdA | gcvP_1 | SRM1_00340 | SRM1_04328 | 2,2-dialkylglycine decarboxylase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.780 |
| dgdA | metH | SRM1_00340 | SRM1_02950 | 2,2-dialkylglycine decarboxylase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.702 |
| dgdA | phnW_1 | SRM1_00340 | SRM1_02571 | 2,2-dialkylglycine decarboxylase. | 2-aminoethylphosphonate--pyruvate transaminase. | 0.764 |
| fadH_1 | fumA | SRM1_03528 | SRM1_04395 | 2,4-dienoyl-CoA reductase [NADPH]. | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.969 |
| fadH_1 | gcvP_1 | SRM1_03528 | SRM1_04328 | 2,4-dienoyl-CoA reductase [NADPH]. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.923 |
| fadH_1 | gcvT_2 | SRM1_03528 | SRM1_05305 | 2,4-dienoyl-CoA reductase [NADPH]. | Aminomethyltransferase; Belongs to the GcvT family. | 0.918 |
| fadH_1 | phnW_1 | SRM1_03528 | SRM1_02571 | 2,4-dienoyl-CoA reductase [NADPH]. | 2-aminoethylphosphonate--pyruvate transaminase. | 0.700 |
| fumA | aceA | SRM1_04395 | SRM1_03444 | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Isocitrate lyase. | 0.821 |
| fumA | fadH_1 | SRM1_04395 | SRM1_03528 | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 2,4-dienoyl-CoA reductase [NADPH]. | 0.969 |
| fumA | gcvP_1 | SRM1_04395 | SRM1_04328 | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.976 |
| fumA | metH | SRM1_04395 | SRM1_02950 | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.436 |
| fumA | phnW_1 | SRM1_04395 | SRM1_02571 | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 2-aminoethylphosphonate--pyruvate transaminase. | 0.711 |
| gcvP_1 | dgdA | SRM1_04328 | SRM1_00340 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 2,2-dialkylglycine decarboxylase. | 0.780 |
| gcvP_1 | fadH_1 | SRM1_04328 | SRM1_03528 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 2,4-dienoyl-CoA reductase [NADPH]. | 0.923 |
| gcvP_1 | fumA | SRM1_04328 | SRM1_04395 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.976 |
| gcvP_1 | gcvT_2 | SRM1_04328 | SRM1_05305 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Aminomethyltransferase; Belongs to the GcvT family. | 0.999 |
| gcvP_1 | metH | SRM1_04328 | SRM1_02950 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.915 |
| gcvP_1 | phnW_1 | SRM1_04328 | SRM1_02571 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 2-aminoethylphosphonate--pyruvate transaminase. | 0.700 |