kaiC_1 protein (Pseudomonas fluorescens) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

kaiC_1

Circadian clock protein kinase KaiC. (486 aa)

Predicted Functional Partners:

rcsC_4

0.938

CEL29223.1

0.789

cph1

0.783

bphP_1

0.657

tmk_1

0.613

kdpD

0.605

cssS

0.605

CEL28905.1

0.493

gmr_4

0.457

kaiC_2

0.455

Your Current Organism:

Pseudomonas fluorescens

NCBI taxonomy Id: 294
Other names: ATCC 13525, Bacillus fluorescens, Bacillus fluorescens liquefaciens, Bacterium fluorescen, CCEB 546, CFBP 2102, CIP 69.13, DSM 50090, IAM 12022, IFO 14160, JCM 5963, Liquidomonas fluorescens, NBRC 14160, NCCB 76040, NCIB 9046, NCIB:9046, NCIMB 9046, NCTC 10038, NRRL B-14678, P. fluorescens, Pseudomonas sp. AU2390, Pseudomonas sp. BZ64, Pseudomonas sp. FY32, Pseudomonas sp. HSA2/2016, Pseudomonas sp. HSA3/2016, Pseudomonas sp. ISSDS-433, Pseudomonas sp. JCM 17186, Pseudomonas sp. JCM 2779, Pseudomonas sp. KH-20150KS3, Pseudomonas sp. LBUM223, Pseudomonas sp. LBUM636, Pseudomonas sp. SM2/2016, RH 818, VKM B-894, bacterium P1-1, strain M. Rhodes 28/5

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEL28905.1	bphP_1	SRM1_02253	SRM1_02321	Blue-light-activated protein.	Bacteriophytochrome.	0.845
CEL28905.1	cph1	SRM1_02253	SRM1_02199	Blue-light-activated protein.	Phytochrome-like protein cph1.	0.776
CEL28905.1	cssS	SRM1_02253	SRM1_04206	Blue-light-activated protein.	Sensor histidine kinase CssS.	0.696
CEL28905.1	gmr_4	SRM1_02253	SRM1_02577	Blue-light-activated protein.	Cyclic di-GMP phosphodiesterase Gmr.	0.891
CEL28905.1	kaiC_1	SRM1_02253	SRM1_02575	Blue-light-activated protein.	Circadian clock protein kinase KaiC.	0.493
CEL28905.1	kaiC_2	SRM1_02253	SRM1_02578	Blue-light-activated protein.	Circadian clock protein kinase KaiC.	0.573
CEL28905.1	kdpD	SRM1_02253	SRM1_03980	Blue-light-activated protein.	Sensor protein KdpD.	0.696
CEL28905.1	rcsC_4	SRM1_02253	SRM1_02576	Blue-light-activated protein.	Sensor histidine kinase RcsC.	0.823
CEL29223.1	gmr_4	SRM1_02574	SRM1_02577	Hypothetical protein.	Cyclic di-GMP phosphodiesterase Gmr.	0.426
CEL29223.1	kaiC_1	SRM1_02574	SRM1_02575	Hypothetical protein.	Circadian clock protein kinase KaiC.	0.789
CEL29223.1	rcsC_4	SRM1_02574	SRM1_02576	Hypothetical protein.	Sensor histidine kinase RcsC.	0.791
CEL29223.1	tmk_1	SRM1_02574	SRM1_02573	Hypothetical protein.	Thymidylate kinase.	0.613
bphP_1	CEL28905.1	SRM1_02321	SRM1_02253	Bacteriophytochrome.	Blue-light-activated protein.	0.845
bphP_1	kaiC_1	SRM1_02321	SRM1_02575	Bacteriophytochrome.	Circadian clock protein kinase KaiC.	0.657
bphP_1	kaiC_2	SRM1_02321	SRM1_02578	Bacteriophytochrome.	Circadian clock protein kinase KaiC.	0.701
cph1	CEL28905.1	SRM1_02199	SRM1_02253	Phytochrome-like protein cph1.	Blue-light-activated protein.	0.776
cph1	kaiC_1	SRM1_02199	SRM1_02575	Phytochrome-like protein cph1.	Circadian clock protein kinase KaiC.	0.783
cph1	kaiC_2	SRM1_02199	SRM1_02578	Phytochrome-like protein cph1.	Circadian clock protein kinase KaiC.	0.804
cssS	CEL28905.1	SRM1_04206	SRM1_02253	Sensor histidine kinase CssS.	Blue-light-activated protein.	0.696
cssS	kaiC_1	SRM1_04206	SRM1_02575	Sensor histidine kinase CssS.	Circadian clock protein kinase KaiC.	0.605

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.838

expected number of edges:

12

PPI enrichment p-value:

1.85e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007264

Small GTPase mediated signal transduction

7 of 23

2.13

4.42

1.48e-10

GO:0007163

Establishment or maintenance of cell polarity

5 of 26

1.93

2.64

1.60e-06

GO:0022604

Regulation of cell morphogenesis

4 of 15

2.07

2.3

2.18e-05

GO:0030036

Actin cytoskeleton organization

5 of 49

1.65

1.94

2.18e-05

GO:0007165

Signal transduction

8 of 166

1.33

1.78

4.94e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003924

GTPase activity

9 of 77

1.71

3.64

6.94e-12

GO:0005525

GTP binding

9 of 94

1.62

3.26

1.88e-11

GO:0019901

Protein kinase binding

3 of 24

1.74

1.36

0.0014

GO:0005509

Calcium ion binding

2 of 19

1.67

0.69

0.0438

GO:0043167

Ion binding

11 of 1226

0.6

0.53

2.75e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042995

Cell projection

4 of 31

1.75

1.73

0.00017

GO:0005886

Plasma membrane

8 of 186

1.28

1.67

6.01e-07

GO:0005938

Cell cortex

4 of 78

1.35

0.99

0.0041

GO:0005856

Cytoskeleton

4 of 150

1.07

0.59

0.0320

GO:0016020

Membrane

9 of 1063

0.57

0.42

0.0062

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3834

Pleckstrin homology domain 5, and Small GTPase Rho

4 of 8

2.34

2.98

1.59e-06

CL:3831

Mixed, incl. Small GTPase mediated signal transduction, and Pleckstrin homology domain 5

5 of 22

2.0

2.85

7.39e-07

CL:3778

MAPK signaling pathway - yeast, and Small GTPase mediated signal transduction

6 of 50

1.72

2.48

7.21e-07

CL:4512

COPI vesicle coat, and ARF-like small GTPases

2 of 12

1.86

0.72

0.0421

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

wic04144

Endocytosis

4 of 59

1.47

1.27

0.00090

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9012999

RHO GTPase cycle

8 of 99

1.55

2.66

2.94e-09

MAP-9716542

Signaling by Rho GTPases, Miro GTPases and RHOBTB3

9 of 140

1.45

2.47

8.73e-10

MAP-194315

Signaling by Rho GTPases

8 of 136

1.41

2.17

2.21e-08

MAP-9696273

RND1 GTPase cycle

3 of 9

2.17

1.8

0.00033

MAP-9696270

RND2 GTPase cycle

2 of 2

2.64

1.31

0.0041

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0342

GTP-binding

8 of 42

1.92

4.45

2.50e-12

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005225

Small GTP-binding protein domain

8 of 38

1.97

4.4

1.11e-11

IPR001806

Small GTPase

6 of 21

2.1

3.74

7.40e-09

IPR003578

Small GTPase Rho

4 of 4

2.64

3.36

4.95e-07

IPR027417

P-loop containing nucleoside triphosphate hydrolase

9 of 295

1.13

1.39

4.35e-07

IPR024156

Small GTPase superfamily, ARF type

2 of 4

2.34

0.85

0.0277

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00174

Rho (Ras homology) subfamily of Ras-like small GTPases

5 of 5

2.64

4.65

1.28e-09

SM00177

ARF-like small GTPases

2 of 4

2.34

1.12

0.0086

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