| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CEL29532.1 | CEL29865.1 | SRM1_02883 | SRM1_03219 | Eukaryotic DNA topoisomerase I, catalytic core. | Putative DNA ligase-like protein/MT0965. | 0.870 |
| CEL29532.1 | CEL32136.1 | SRM1_02883 | SRM1_05510 | Eukaryotic DNA topoisomerase I, catalytic core. | Calcineurin-like phosphoesterase superfamily domain protein. | 0.759 |
| CEL29532.1 | dnaN | SRM1_02883 | SRM1_00057 | Eukaryotic DNA topoisomerase I, catalytic core. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.773 |
| CEL29532.1 | gyrB | SRM1_02883 | SRM1_00059 | Eukaryotic DNA topoisomerase I, catalytic core. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.792 |
| CEL29532.1 | parE | SRM1_02883 | SRM1_00552 | Eukaryotic DNA topoisomerase I, catalytic core. | DNA topoisomerase 4 subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.792 |
| CEL29532.1 | polB | SRM1_02883 | SRM1_03668 | Eukaryotic DNA topoisomerase I, catalytic core. | DNA polymerase II. | 0.775 |
| CEL29532.1 | recQ_1 | SRM1_02883 | SRM1_00325 | Eukaryotic DNA topoisomerase I, catalytic core. | ATP-dependent DNA helicase RecQ. | 0.779 |
| CEL29532.1 | recQ_2 | SRM1_02883 | SRM1_01456 | Eukaryotic DNA topoisomerase I, catalytic core. | ATP-dependent DNA helicase RecQ. | 0.779 |
| CEL29532.1 | rnhB | SRM1_02883 | SRM1_01143 | Eukaryotic DNA topoisomerase I, catalytic core. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.838 |
| CEL29532.1 | sbcD | SRM1_02883 | SRM1_03039 | Eukaryotic DNA topoisomerase I, catalytic core. | Nuclease SbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.759 |
| CEL29865.1 | CEL29532.1 | SRM1_03219 | SRM1_02883 | Putative DNA ligase-like protein/MT0965. | Eukaryotic DNA topoisomerase I, catalytic core. | 0.870 |
| CEL29865.1 | CEL32136.1 | SRM1_03219 | SRM1_05510 | Putative DNA ligase-like protein/MT0965. | Calcineurin-like phosphoesterase superfamily domain protein. | 0.487 |
| CEL29865.1 | dnaN | SRM1_03219 | SRM1_00057 | Putative DNA ligase-like protein/MT0965. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.931 |
| CEL29865.1 | polB | SRM1_03219 | SRM1_03668 | Putative DNA ligase-like protein/MT0965. | DNA polymerase II. | 0.836 |
| CEL29865.1 | recQ_1 | SRM1_03219 | SRM1_00325 | Putative DNA ligase-like protein/MT0965. | ATP-dependent DNA helicase RecQ. | 0.470 |
| CEL29865.1 | recQ_2 | SRM1_03219 | SRM1_01456 | Putative DNA ligase-like protein/MT0965. | ATP-dependent DNA helicase RecQ. | 0.470 |
| CEL29865.1 | sbcD | SRM1_03219 | SRM1_03039 | Putative DNA ligase-like protein/MT0965. | Nuclease SbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.487 |
| CEL32136.1 | CEL29532.1 | SRM1_05510 | SRM1_02883 | Calcineurin-like phosphoesterase superfamily domain protein. | Eukaryotic DNA topoisomerase I, catalytic core. | 0.759 |
| CEL32136.1 | CEL29865.1 | SRM1_05510 | SRM1_03219 | Calcineurin-like phosphoesterase superfamily domain protein. | Putative DNA ligase-like protein/MT0965. | 0.487 |
| CEL32136.1 | dnaN | SRM1_05510 | SRM1_00057 | Calcineurin-like phosphoesterase superfamily domain protein. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.428 |
