| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cobB_2 | rebM_2 | SRM1_03396 | SRM1_03395 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. | Demethylrebeccamycin-D-glucose O-methyltransferase. | 0.581 |
| cysS | metH | SRM1_03483 | SRM1_02950 | Cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.763 |
| cysS | rebM_2 | SRM1_03483 | SRM1_03395 | Cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Demethylrebeccamycin-D-glucose O-methyltransferase. | 0.654 |
| cysS | rsmA | SRM1_03483 | SRM1_05238 | Cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.528 |
| gltB | metH | SRM1_00466 | SRM1_02950 | Glutamate synthase [NADPH] large chain precursor. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.467 |
| gltB | rebM_2 | SRM1_00466 | SRM1_03395 | Glutamate synthase [NADPH] large chain precursor. | Demethylrebeccamycin-D-glucose O-methyltransferase. | 0.694 |
| metH | cysS | SRM1_02950 | SRM1_03483 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.763 |
| metH | gltB | SRM1_02950 | SRM1_00466 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glutamate synthase [NADPH] large chain precursor. | 0.467 |
| metH | rebM_2 | SRM1_02950 | SRM1_03395 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Demethylrebeccamycin-D-glucose O-methyltransferase. | 0.627 |
| rebM_1 | rebM_2 | SRM1_03387 | SRM1_03395 | Demethylrebeccamycin-D-glucose O-methyltransferase. | Demethylrebeccamycin-D-glucose O-methyltransferase. | 0.457 |
| rebM_2 | cobB_2 | SRM1_03395 | SRM1_03396 | Demethylrebeccamycin-D-glucose O-methyltransferase. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. | 0.581 |
| rebM_2 | cysS | SRM1_03395 | SRM1_03483 | Demethylrebeccamycin-D-glucose O-methyltransferase. | Cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.654 |
| rebM_2 | gltB | SRM1_03395 | SRM1_00466 | Demethylrebeccamycin-D-glucose O-methyltransferase. | Glutamate synthase [NADPH] large chain precursor. | 0.694 |
| rebM_2 | metH | SRM1_03395 | SRM1_02950 | Demethylrebeccamycin-D-glucose O-methyltransferase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.627 |
| rebM_2 | rebM_1 | SRM1_03395 | SRM1_03387 | Demethylrebeccamycin-D-glucose O-methyltransferase. | Demethylrebeccamycin-D-glucose O-methyltransferase. | 0.457 |
| rebM_2 | rlmD | SRM1_03395 | SRM1_04164 | Demethylrebeccamycin-D-glucose O-methyltransferase. | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. | 0.441 |
| rebM_2 | rlmE | SRM1_03395 | SRM1_00817 | Demethylrebeccamycin-D-glucose O-methyltransferase. | Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | 0.567 |
| rebM_2 | rpmD | SRM1_03395 | SRM1_05161 | Demethylrebeccamycin-D-glucose O-methyltransferase. | 50S ribosomal protein L30. | 0.657 |
| rebM_2 | rsmA | SRM1_03395 | SRM1_05238 | Demethylrebeccamycin-D-glucose O-methyltransferase. | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.444 |
| rebM_2 | trmB | SRM1_03395 | SRM1_05424 | Demethylrebeccamycin-D-glucose O-methyltransferase. | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | 0.672 |