| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bioF_2 | hemB_1 | SRM1_05276 | SRM1_03680 | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.696 |
| bioF_2 | hemB_2 | SRM1_05276 | SRM1_05606 | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.696 |
| bioF_2 | hemL | SRM1_05276 | SRM1_05022 | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.916 |
| cobM | cysG | SRM1_02946 | SRM1_03423 | Precorrin-4 C(11)-methyltransferase. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.959 |
| cobM | hemA | SRM1_02946 | SRM1_04800 | Precorrin-4 C(11)-methyltransferase. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.565 |
| cobM | hemB_1 | SRM1_02946 | SRM1_03680 | Precorrin-4 C(11)-methyltransferase. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.720 |
| cobM | hemB_2 | SRM1_02946 | SRM1_05606 | Precorrin-4 C(11)-methyltransferase. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.684 |
| cobM | hemC | SRM1_02946 | SRM1_05626 | Precorrin-4 C(11)-methyltransferase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.744 |
| cobM | hemL | SRM1_02946 | SRM1_05022 | Precorrin-4 C(11)-methyltransferase. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.560 |
| cobM | sumT_1 | SRM1_02946 | SRM1_01867 | Precorrin-4 C(11)-methyltransferase. | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.519 |
| cysG | cobM | SRM1_03423 | SRM1_02946 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Precorrin-4 C(11)-methyltransferase. | 0.959 |
| cysG | hemA | SRM1_03423 | SRM1_04800 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.940 |
| cysG | hemB_1 | SRM1_03423 | SRM1_03680 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.963 |
| cysG | hemB_2 | SRM1_03423 | SRM1_05606 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.962 |
| cysG | hemC | SRM1_03423 | SRM1_05626 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
| cysG | hemD | SRM1_03423 | SRM1_05625 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen-III synthase. | 0.949 |
| cysG | hemE | SRM1_03423 | SRM1_00468 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.985 |
| cysG | hemL | SRM1_03423 | SRM1_05022 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.970 |
| cysG | sumT_1 | SRM1_03423 | SRM1_01867 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.980 |
| hemA | cobM | SRM1_04800 | SRM1_02946 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Precorrin-4 C(11)-methyltransferase. | 0.565 |
