| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glnQ_5 | phnC | SRM1_03071 | SRM1_02351 | Glutamine transport ATP-binding protein GlnQ. | Phosphate-import ATP-binding protein PhnC. | 0.929 |
| glnQ_5 | phnD_2 | SRM1_03071 | SRM1_03070 | Glutamine transport ATP-binding protein GlnQ. | Phosphate-import protein PhnD precursor. | 0.999 |
| glnQ_5 | phnE_3 | SRM1_03071 | SRM1_03072 | Glutamine transport ATP-binding protein GlnQ. | Phosphate-import permease protein PhnE. | 0.999 |
| glnQ_5 | phnN | SRM1_03071 | SRM1_04213 | Glutamine transport ATP-binding protein GlnQ. | Ribose 1,5-bisphosphate phosphokinase PhnN. | 0.873 |
| hisG | hisZ | SRM1_00917 | SRM1_00586 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.999 |
| hisG | phnN | SRM1_00917 | SRM1_04213 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | Ribose 1,5-bisphosphate phosphokinase PhnN. | 0.918 |
| hisG | prs_1 | SRM1_00917 | SRM1_04805 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.975 |
| hisG | purF | SRM1_00917 | SRM1_01997 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.496 |
| hisZ | hisG | SRM1_00586 | SRM1_00917 | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.999 |
| hisZ | phnN | SRM1_00586 | SRM1_04213 | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | Ribose 1,5-bisphosphate phosphokinase PhnN. | 0.918 |
| hisZ | prs_1 | SRM1_00586 | SRM1_04805 | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.964 |
| phnC | glnQ_5 | SRM1_02351 | SRM1_03071 | Phosphate-import ATP-binding protein PhnC. | Glutamine transport ATP-binding protein GlnQ. | 0.929 |
| phnC | phnD_2 | SRM1_02351 | SRM1_03070 | Phosphate-import ATP-binding protein PhnC. | Phosphate-import protein PhnD precursor. | 0.995 |
| phnC | phnE_3 | SRM1_02351 | SRM1_03072 | Phosphate-import ATP-binding protein PhnC. | Phosphate-import permease protein PhnE. | 0.986 |
| phnC | phnN | SRM1_02351 | SRM1_04213 | Phosphate-import ATP-binding protein PhnC. | Ribose 1,5-bisphosphate phosphokinase PhnN. | 0.663 |
| phnD_2 | glnQ_5 | SRM1_03070 | SRM1_03071 | Phosphate-import protein PhnD precursor. | Glutamine transport ATP-binding protein GlnQ. | 0.999 |
| phnD_2 | phnC | SRM1_03070 | SRM1_02351 | Phosphate-import protein PhnD precursor. | Phosphate-import ATP-binding protein PhnC. | 0.995 |
| phnD_2 | phnE_3 | SRM1_03070 | SRM1_03072 | Phosphate-import protein PhnD precursor. | Phosphate-import permease protein PhnE. | 0.998 |
| phnD_2 | phnN | SRM1_03070 | SRM1_04213 | Phosphate-import protein PhnD precursor. | Ribose 1,5-bisphosphate phosphokinase PhnN. | 0.922 |
| phnE_3 | glnQ_5 | SRM1_03072 | SRM1_03071 | Phosphate-import permease protein PhnE. | Glutamine transport ATP-binding protein GlnQ. | 0.999 |