| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cysG | cysNC | SRM1_03423 | SRM1_00926 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Bifunctional enzyme CysN/CysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.970 |
| cysG | gltB | SRM1_03423 | SRM1_00466 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Glutamate synthase [NADPH] large chain precursor. | 0.725 |
| cysG | pitA_2 | SRM1_03423 | SRM1_04263 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Low-affinity inorganic phosphate transporter 1. | 0.542 |
| cysNC | cysG | SRM1_00926 | SRM1_03423 | Bifunctional enzyme CysN/CysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.970 |
| cysNC | gltB | SRM1_00926 | SRM1_00466 | Bifunctional enzyme CysN/CysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | Glutamate synthase [NADPH] large chain precursor. | 0.738 |
| cysNC | pitA_2 | SRM1_00926 | SRM1_04263 | Bifunctional enzyme CysN/CysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | Low-affinity inorganic phosphate transporter 1. | 0.499 |
| cysNC | pstA | SRM1_00926 | SRM1_05761 | Bifunctional enzyme CysN/CysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | Phosphate transport system permease protein PstA. | 0.800 |
| cysNC | pstB | SRM1_00926 | SRM1_05760 | Bifunctional enzyme CysN/CysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | Phosphate import ATP-binding protein PstB; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. | 0.454 |
| cysNC | trpA | SRM1_00926 | SRM1_00163 | Bifunctional enzyme CysN/CysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.511 |
| dapB | pitA_2 | SRM1_00811 | SRM1_04263 | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | Low-affinity inorganic phosphate transporter 1. | 0.448 |
| dapB | trpA | SRM1_00811 | SRM1_00163 | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.410 |
| gltB | cysG | SRM1_00466 | SRM1_03423 | Glutamate synthase [NADPH] large chain precursor. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.725 |
| gltB | cysNC | SRM1_00466 | SRM1_00926 | Glutamate synthase [NADPH] large chain precursor. | Bifunctional enzyme CysN/CysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.738 |
| gltB | phoU | SRM1_00466 | SRM1_05759 | Glutamate synthase [NADPH] large chain precursor. | Phosphate-specific transport system accessory protein PhoU; Plays a role in the regulation of phosphate uptake. | 0.627 |
| gltB | pitA_2 | SRM1_00466 | SRM1_04263 | Glutamate synthase [NADPH] large chain precursor. | Low-affinity inorganic phosphate transporter 1. | 0.554 |
| gltB | pstA | SRM1_00466 | SRM1_05761 | Glutamate synthase [NADPH] large chain precursor. | Phosphate transport system permease protein PstA. | 0.706 |
| gltB | pstB | SRM1_00466 | SRM1_05760 | Glutamate synthase [NADPH] large chain precursor. | Phosphate import ATP-binding protein PstB; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. | 0.618 |
| gltB | trpA | SRM1_00466 | SRM1_00163 | Glutamate synthase [NADPH] large chain precursor. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.894 |
| phoR_2 | phoU | SRM1_05755 | SRM1_05759 | Phosphate regulon sensor protein PhoR. | Phosphate-specific transport system accessory protein PhoU; Plays a role in the regulation of phosphate uptake. | 0.877 |
| phoR_2 | pitA_2 | SRM1_05755 | SRM1_04263 | Phosphate regulon sensor protein PhoR. | Low-affinity inorganic phosphate transporter 1. | 0.546 |